Cell 
Volume 63 Nur ; Novemwr } 
Crystal Structure 
of Homeodomaln-DNA Complex 
A representation of the structure of the engrailed homeodomain-DNA complex 
as determined by x-ray crystallography. The protein ( shown in red and yellow ) 
binds to the DNA (blue) and makes numerous contacts with a 4-base pair 
region (purple) of the double-helical DNA. One a- helix from the homeodomain 
(which looks like a red circle in projection) fits into the major groove of the 
DNA, and an extended region of the protein backbone ( which appears as a red 
ribbon in the figure) fits into the minor groove of the DNA. 
This structure was determined by Charles Kissinger and Carl Pabo. Illustra- 
tion originally printed as cover o/Cell 63(3), 1990. See also Kissinger, C.R., 
Liu, B., Martin- Blanco, E., Kornberg, T.B., and Pabo, CO. 1990. Cell 
63:579-590. 
