The Yeast Secretory Pathway 
SEC (secretory) genes regulate the flow of yeast secretory polypeptides into and from the endo- 
plasmic reticulum (ER) and through the Golgi complex. In the Golgi, proteins destined for secre- 
tion are sorted from vacuolar /lysosomal proteins. Mature secretory proteins are packaged into 
vesicles and directed to the inner surface of the growing yeast hud. The secretory process and the 
SEC gene products are very similar in yeast and mammalian cells. 
Research of Randy W. Schekman. 
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