THE HUMAN T CELL ANTIGEN RECEPTOR 
Extracellular 
Membrane 
Cytoplasm 
Model of the structure of the human Tcell antigen receptor. Basic and acidic amino acid residues 
present in the transmembrane domains of each of the chains of the receptor are indicated by the 
one-letter amino acid code (D~, aspartic acid; E', glutamic acid; R* , arginine; K"^, lysine ). Vand 
C of the Ti chains correspond to variable and constant domains within these immunoglobulin- 
like chains involved in antigen recognition. The ^-chain dimer and the y-, 8-, and e-chains of the 
CD3/T3 complex are believed to function in signal transduction. 
Research of Arthur Weiss. 
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