Index 
A2.1 molecule, antigen presentation, 103-104 
/437gene, peripheral nervous system development, 36 
abd-A gene, Drosophila development, xxv 
ABL oncogene, growth regulation, 483-484 
Acetylcholine receptor (AChR), li, liv 
achaete- scute complex (AS-C) , pattern formation and, 73- 74 
Acquired immune deficiency syndrome (AIDS) 
co-receptor function and, xlviii-xlix 
gene regulation, 355 
lymphoid cell growth and development, 445-446 
retroviral gene expression, 313-314 
retroviral replication, 60-62 
T cell growth and, 1 77- 1 78 
tuberculosis and, 214-216 
Action potentials 
functions of, / 
nerve cells, 1-3 
neuromuscular function and, li, liii 
synaptic events, xxxii-xxxiii 
Adducin, 40 
Adenosine deaminase (ADA) 
blood cell formation, 478 
deficiency, genetic correction of, 75 
hematopoietic stem cells, 37-38 
protein structure and function, 360-362 
Adenovirus, gene expression and oncogenesis, 403-404 
Adrenergic receptors 
hormone and drug receptors, 273-275 
signal transduction, 247-248 
/3-Adrenergic receptor kinase (/?ARK), 274 
Adult T cell leukemia, mechanisms of, 177-178 
Affective disorders, genetic studies and, Ivi 
AFP (a-fetoprotein) , embryogenesis, 449-450 
Agrin 
neuroimmunology, 349 
synaptic transmission, 204, 384-386 
Albinism, pigmentation and insertional mutagenesis, 
337-338 
Aldosterone synthetase gene, hypertension and, 348 
Alleles, major histocompatibility complex (MHC), xlviii 
a-2 protein, DNA-protein interactions, 339-341 
Alternative splicing 
gene regulation, 323-324 
genetic disease tracking, 89-90 
protein diversity, 315-316 
Amino acids 
cell development, xxvi 
inborn errors of metabolism, 271-272 
Amylin, islet hormone evolution, 423-424 
Animal cells, gene regulation, 451-452 
Ankyrin, in nervous system, 39-40 
ANT-C homeotic loci, Drosophila morphogenesis, 239-240 
Antennapedia gene complex 
development, 379-380 
morphogenesis, 239-240 
Antenna-specific aldehyde oxidase (AOX), olfaction system, 
283-284 
Antibiotics, mycobacterial disease, 214-216 
Antibodies 
autoimmune and self-tolerance mechanisms, 1 74- 1 76 
complement system, 21-22 
functions of, xlvii-xlix 
generation mechanisms, 11-12 
gene rearrangements, 111-112 
immune response, xlii 
molecular structure, xliv, xlvii 
specificity, T cell receptors, xlii, xliv, xlvii 
Antigen-antigen interaction, protein structure and function, 
362 
Antigenic determinant, xlvii 
immune system, xlvii 
Antigen presentation 
immune system, xlvii 
T lymphocyte biology and, 369-370 
Antigen-presenting cell (APC), lymphocyte surface antigens, 
389-390 
Antigens 
complement system, xlvii-xlix 
immune response, xlii 
presentation mechanisms, 103-104 
receptor genes, 11-12 
Antitumor effects, 270 
AP I gene network, 127-128 
Apolipoprotein E, structural studies, 4, 6 
Argininosuccinate synthetase (AS), in urea cycle, 31-32 
Atrial natriuretic peptide, 151-152 
Autoantibody probes, mammalian gene expression, 425-426 
Autoimmune disorders 
complement system, 21-22 
immune system and, xlvii 
self-tolerance mechanisms and, 174-176 
See also Diabetes mellitus 
Autoimmunity 
antigen-specific T cell receptors, 291 
mechanisms of, / 74- 1 76 
self/non-self discrimination, 221-222 
Autosomal dominant polycystic kidney disease (ADPKD), 
365 
Autosomal recessive hypopituitarism, 144 
Avian leukemia virus (ALV), gene expression regulation, 99 
Axons 
functions of, / 
guidance, Drosophila visual system, 430-432 
pathfinding, 367-368 
synaptic events, xxxii-xxxiii 
Bacteriophages, vaccine research, 215-216 
Bare lymphocyte syndrome (BLS), gene regulation, 355 
Basement membrane collagen, kidney disease, 365 
Base-pairing, genome structure, xxxv, xxxvii 
B cells 
autoimmune and self-tolerance mechanisms, 174-176 
cell activity, 411 
complement receptors, 195-196 
developmental genetics, 11-12, 329-330 
gene expression, 413-414 
immune response, xlii-xliii 
immune system development, 91-92 
lymphoid cell grovrth and development, 445-446 
mammalian development, xlv, xlvii 
molecular differentiation mechanisms, 111-112 
BCG (bacille Calmette-Guerin) vaccine, tuberculosis and, 
215-216 
BCR/ABL gene product, growth regulation, 483-484 
Becker muscular dystrophy, molecular genetics of, 251-252 
Beckwith-Wiedemann syndrome, gene inactivation, 132 
Betaglycan, transforming growth factors, 301-302 
bicoid (bed) gene 
Z>rosop*?7« development, 114-116 
morphogen gradients, 437 
Biological clock, neuromuscular behavior, 493-494 
BiP/GRP78 protein, autoimmune model, 159-160 
bithorax complex (BX-C), Drosophila development, 
379-380 
fe/* gene, lymphocyte activation, 112 
Blood cells 
formation, 477-478 
structural proteins, 39-40 
Blood coagulation 
gene regulation of, 377-378 
molecular genetics, 162-164 
prevention mechanisms, 125-126 
505 
