Index 
Blood groups, glycosyltransferases, 293-294 
Blue cone monochromacy, pigment gene characterization, 
320 
Bone marrow 
blood cell formation studies, 477-478 
transplants, blood coagulation and, 162-164 
Borrelia burgdorferi, immune response and, 136-138 
Bovine pancreatic trypsin inhibitor (BPTI), protein folding, 
242-244 
C3 complement component, 195- 196 
6C3/BP-1 antigen, lymphocyte life cycle, 467-468 
C4b-binding protein (C4bBP), blood clot prevention and, 
125-126 
Cachexia, tumor necrosis factor and, 41-42 
Cadherin, neuron development, 368 
Caenorhabditis elegans 
development, 197-199 
genetic studies, xl 
linkage mapping, 62 
molecular genetics and, 433-434 
Calcitonin gene-regulated peptide (CGRP) 
gene activation, 374-375 
neural gene expression and, 14 
synaptic transmission, 204 
Calcium 
hormone mediation, 129-130 
molecular engineering and, 455-456 
molecular physiology, 459-460 
phototransduction, 489-490 
protein structure and function, 362 
Calcium-binding protein, signal transduction, 205-206 
Calcium/calmodulin-sensitive kinase II (CaMK-II), memory 
cell studies, 233-234 
Calcium ion channels 
dystrophin-glycoprotein complex, 69- 70 
hippocampus neurobiology, 399-400 
nerve cell electrical activity, 1-3 
synaptic function, 407-408 
Calmodulin-dependent protein kinase 
calcium physiology, 459-460 
second messenger pathways, 391-392 
Calmodulin-regulated ion channels, 459-460 
cAMP (cyclic AMP) 
DNA-binding proteins and, 182-184 
molecular engineering and, 455-456 
synaptic neuromodulation, 435-436 
cAMP response element (CRE) 
oncogenesis and gene expression, 403-404 
T cell receptor gene expression, 280-281 
cAMP-responsive enhancer-binding proteins (CREBs), 184 
Cancer 
biological control genetics, 269-270 
cell adhesion, 207-209 
genetic studies of, xl-xli 
growth factor response, 317-318 
molecular genetics, 131-132 
Capillary gel electrophoresis, DNA sequencing, 157-158 
Carbohydrates 
antibody molecule structure, xliv, xlvii 
protein structure and function, 362 
Cardiac muscle, molecular analysis, 280-282 
Cardiac troponin C (cTnC), molecular analysis, 280-282 
Carrier detection, metabolic disorders, 487-488 
Cassettes, B and T lymphocytes, 11-12 
Catabolite gene activator protein (CAP), protein-DNA 
interaction, 427-429 
Cation channels 
amino acids, retroviral infection, 101 
virus, 266 
CCAAT/enhancer-binding protein (C/EBP), transcription 
factor, 307-308 
CCK prohormone, cholecystokinin regulation, 146 
CD3 complex, T cell antigen receptor, 464-466 
CD4 molecule 
antigen presentation, 103-104 
immune function and tolerance, 136-138 
major histocompatibility complex (MHC), xlviii-xlix 
receptor diversity in, 24 
T lymphocytes 
functional heterogeneity, 57-58 
surface glycoproteins, 289-290 
CDS molecule 
immune function and tolerance, 136-138 
major histocompatibility complex (MHC), xlviii 
T cell surface glycoproteins, 289-290 
CD18 molecule, genetic disease, 32 
CD28 molecule, lymphoid cell growth and development, 
445-446 
CD45 protein, T cell antigen receptor, 464-466 
cdc2 units, cell cycle studies, 27-28 
cDNA 
gene expression, 180 
insulin receptor studies, 123-124 
libraries, Down syndrome analysis, 256 
neural gene expression and, 13-14 
neurofibromatosis type 1 (NFl), 472-474 
Cell adhesion 
extracellular matrix, xxxii-xxxiv 
genetic disease, 32 
nectins and integrins, 207-209 
neuronal recognition and, 171-173 
neuron development, 368 
Cell-cell interaction 
membrane-anchored grovwh factors, 302 
phenotypes, Iv 
proto-oncogenes, 327-328 
Cell cycle 
control of, 27-28, 297-298 
determination and maintenance, 169-170 
gene expression, 189-190 
gene regulation, xxxi-xxxii 
metabolism, peptides in, 182-184 
molecular engineering and, 455-456 
regulation, chemistry of, 409-410 
S phase, 297-298 
transforming groviih factors, 301-302 
Cell differentiation. See Differentiation 
Cell fate 
death, nematode development and, 197-199 
determination and maintenance, 169-170 
signal transduction, 353-354 
vertebrate neuronal development, 15-16 
Cell growth 
density, determination and maintenance, 169-170 
liver regeneration, 443-444 
structural studies, xxv-xxvi 
Cell lineage, nematode development, 197-199 
Cell-mediated immunity 
helper T cells, xlii 
leprosy and, 51-52 
Cell membranes 
insulating property, 1 
membrane lipids and, 167 
structural studies, 4-6 
Cell migration, nematode development, 198-199 
Cell motility, cytoskeleton structure, xxxi 
Cell patterning. See Pattern formation 
i8 Cells, of pancreas 
diabetes and, xlvii 
islet hormone and insulin action, 423-424 
Cell signaling, nematode development, 197-199 
Cellular asymmetry, nematode development, 433-434 
Central nervous system, cell patterning, 224-226 
506 
