Index 
Differentiation {continued) 
muscle cells, 316 
T lymphocyte control, 106 
transforming growth factors, 301-302 
DiGeorge syndrome, 71 
Dimerization, transcription factor, 307-308 
Disease genes 
cancep,-2(>5'- 2 70 
genetic correction of, 75- 76 
heat-shock proteins, 287-288 
identification and correction, 142-144 
retroviral replication and, 60-62 
Distal-less gene, limb development, 86-88 
Diversity 
antigen presentation, 103-104 
sequence, T cell receptors, xlii, xlvii 
DJ element, antibody gene rearrangement, 111-112 
DNA 
double-helix structure, xxxv 
structural studies of, xxxv-xxxvi 
DNA-binding protein 
cAMP-dependent, 182-184 
eukaryotic gene regulation and, 67-68 
fingerprinting, xl 
See also Gene mapping 
gene regulation, xxxv, xxxvii 
homeodomains, 115-116 
methylation, malignant transformation and, 131-132 
photolyase, macromolecule structure, 109-110 
sequences, replication and, xxxv-xxxvi 
structural studies, 339-341 
DNA polymerase III, replication mechanisms, 331-332 
DNA polymorphisms, diabetes-prone genetics and, 33-34 
DNA-protein interactions 
gene regulation, 340-341 
lymphocyte differentiation, 303-305 
structural studies, 427-429 
DNA synthesis 
cell cycle, 297-298 
gene expression, 189-190 
downless gene, pigmentation and insenional mutagenesis, 
338 
Down syndrome, molecular analysis, 255-256 
Drosophila 
chromosome organization and gene function, 193-194 
development 
limb genetics, 86-88 
molecular genetics, 379-380 
nervous system, Iv, 219-220 
neuromuscular behavior, 493-494 
neuronal cells, 15-16 
peripheral nervous system (PNS), 35-36 
proto-oncogenes, 327-328 
segmentation and pattern formation, 72-74 
transcription control, 114-116 
visual system, 237 
egg genetics, 417-418 
eukaryotic chromosome structure, 394-396 
in genetic studies, xl 
homeotic gene action, 29-30 
metamorphosis, 447-448 
morphogenesis, 239-240 
gradients, 437-438 
neurogenesis in, 18-20 
neuronal recognition in, 171-173 
pattern formation and germline determination, 277-278 
position-dependent gene expression, 187-188 
visual system 
development of, 23 7 
pattern formation and neuronal cell recognition, 
430-432 
phototransduction, 489-490 
pigment molecular biology, 319-321 
pigmentation and insertional mutagenesis, 337-338 
sevenless gene, 375-376 
signal transduction, 205-206 
transduction, 497 
DRwl 1 molecules, lymphocyte surface antigens, 389-390 
Duchenne muscular dystrophy 
genetic correction of, 75- 76 
molecular genetics of, 251-252 
X chromosomes, xxix, 402 
Dwarfism, gene mapping and, 142-144 
Dyad symmetry, transcription factor, 307-308 
Dystrophin 
molecular genetics of, 251-252 
muscular development and, xxxix 
muscular dystrophy pathogenesis, Iv, 69- 70 
X chromosomes, 402 
Dystrophin-glycoprotein complex, 69-70 
calcium channels, 69- 70 
Dystrophin-related protein (DRP), molecular genetics of, 
251-252 
ElA gene 
oncogenesis and gene expression, 403-404 
viral-mediated trans-activation, 323-324 
E2F factor, viral-mediated trans-activation, 323-324 
E74 protein, metamorphosis, 447-448 
Early-growth response (EGR), growth factors, 441 
Ecdysone, metamorphosis, 447-448 
Effector mechanisms, histocompatibility and, 79-80 
Egg-laying hormone (ELH), synaptic transmission, 384-386 
Eggs, genetic analysis, 417-418 
ELAM-I (endothelial leukocyte adhesion molecule-I), 294 
EUiptocytosis, 232 
Embryogenesis 
proto-oncogenes, 327-328 
scrgene, 239-240 
Embryonic induction, vertebrates, 295-296 
Embryonic stem (ES) cells 
blood cell formation studies, 477-478 
developmental genetics, 415-416 
gene targeting and, 71 
hematopoietic, 37-38 
recessive gene inactivation, 26 
T cell development and function, 453-454 
Encoded proteins, immunoglobulin heavy-chain gene, 
229-230 
Endoplasmic reticulum (ER) 
mammalian cell development, xxvii 
protein synthesis, xxx-xxxi 
protein translocation, 381-383 
Endothelial cells, blood coagulation, 378 
Endotoxin, TNF release and, 41-42 
Engrailed (En) protein, 
homeodomains and, 379-380 
transcriptional function, 114-116 
Enhanced stability, engineering proteins, 303-305 
Enhancer 
immunoglobulin heavy-chain gene, 229-230 
trap, neuronal recognition and, 171-173 
Enteric bacteria, pathogenicity studies, 387-388 
Enteropathogenic strains of Escherichia coli (EPEC), 
387-388 
e«f genes, retroviral gene expression, 99-100 
Enzymes 
specificity, structural basis of, 4-6 
structural studies of, Ivii-lviii 
Epidermal growth factor (EGF), 302 
cell proliferation, 479-480 
desensitization, 357-358 
gene regulation, 441 
genomic response, 317-318 
508 
