^^^^^ 
Index 
hormonal signal transduction, 422 
membrane and secretory proteins, 160 
molecular genetics and, 433-434 
neuroimmunology, 349 
signal transduction, 107-108 
synaptic transmission, 386 
transcription, 495-496 
Epidermolysis bullosa simplex (EBS), 148-150 
Epithelial cells, human papillomaviruses, 259-260 
Epitopes 
immune response, xlii 
JR-8D2 epitope, Drosophila neurogenesis, 18 
protein structure and function, 360-362 
Epstein-Barr virus (EBV) 
autoantibody probes, 425-426 
complement receptors, 195- 196 
erfefi oncogene, tissue specificity, 108 
Erythroblastosis, tissue specificity, 108 
"Erythroid" proteins, molecular genetics, 335-336 
Escherichia coli, lactose permease, 227-228 
E(spl) gene, Drosophila neurogenesis and, 19-20 
Estrogen receptor, cellular regulation, 409-410 
efsgene, metamorphosis, 447-448 
Eukaryotic chromosomes, three-dimensional structure, 
394-396 
Eukaryotic gene regulation, molecular recognition, 67-68 
EVI2B gene, neurofibromatosis type 1 (NFl), 472-474 
Ewing's sarcoma, cholecystokinin regulation, 146 
Excitation-contraction coupling, skeletal muscle, 69-70 
Excitatory postsynaptic potential (EPSP), computational 
neurobiology, 399-400 
Exocytosis, neurotransmitter release, 439-440 
Exons 
mammalian cell development, xxvi 
RNA polymerase II, 93-94 
"Expression sites," immune evasion, 117-118 
Extracellular matrix, cell adhesion, xxxii-xxxiii 
Fab fragments, macromolecule structure, Ivii 
insulin receptor studies, 123-124 
molecular biology of, 53-54 
neuron development, 367-368 
Factor V, blood clot prevention and, 125-126 
Factor VIII 
blood clot prevention and, 125-126 
blood coagulation and, 162-164 
hemophilia A, 165-166 
Familial hypercholesterolemia (FH), somatic gene therapy, 
481 
Familial hypertrophic cardiomyopathy (FHC), myosin 
heavy-chain mutations, 35*7 
Farnesyl groups, cell regulation, 167 
Fasciclin proteins, neuronal recognition and, 171-173 
fat genes 
neuronal recognition and, 171-173 
molecular basis of obesity and, 145-146 
Fc fragments 
in macromolecules, Ivii 
structural studies of, 45-46 
Feeding behavior, molecular biology of, 145-146 
Fertilization, molecular basis of, 151-152 
Fibrinolysis, blood coagulation and, 162-164 
Fibroblast growth factor (FGF) 
cell proliferation, 479-480 
hormonal signal transduction, 422 
neuronal development, 15-16 
Fibronectins, cell adhesion, 207-209 
Fission yeast, cell cycle studies, 27-28 
Fixed water molecule, cellular regulation, 409-410 
Floor plate, nervous system development, 224-226 
Fluorescence spectroscopy 
eukaryotic chromosome structure, 394-396 
extracellular matrix, xxxii-xxxiii 
molecular engineering and, 455-456 
Fluorescence-activated cell sorter (FACS), homeobox 
proteins, 296 
FMRFamide, synaptic function, 407-408 
Four-dimensional optical microscopy, eukaryotic 
chromosome structure, 394-396 
Fragile sites, kidney disease, 365 
Fragile X chromosome 
isolation and molecular diagnostics, 76 
kidney disease, 365 
molecular genetics, 325 
FRED protein, viral fusion activity, 266 
Free-energy perturbation, macromolecular simulation, 66 
Fused genes, embryogenesis, 449-450 
Fushi tarazu (Ftz) gene product, transcription, 1 14-116 
Fusion activity, in viruses, 266 
fyn genes 
embryonic stem cells, 416 
lymphocyte signaling, 351 
Gl cyclins, CSF- 1 -responsive genes, 406 
G2 cyclins, cell cycle, 297-298 
GAL4 proteins, regulatory complexes, 186 
i8-Galactosidase 
developmental genetics, 415-416 
reporter gene, peripheral nervous system, 35-36 
Gap genes, Drosophila development, 1 14-1 16 
GART genes, YAC library, 334 
Gart locus, chromosome organization, 193-194 
GCN4, helix-helix association, 66 
Gene activation 
cancer development, 131-132 
developmental programs, 373-374 
Gene amplification, oncogenic potential, 155-156 
Gene assembly 
B and T lymphocytes, 11-12 
mammalian cell development, xxvi, xxviii 
Gene cloning. See Cloning 
Gene expression 
autoantibody probes, 425-426 
cell cycle, 189-190 
cell differentiation and activation, 280-282 
cellular transcription, 313-314 
developmental control, 179-180 
developmental programs, 374 
a-globin, 285-286 
globins, 231-232 
hormonal regulation of, 81-82 
liver regeneration, 443-444 
lymphocyte development, 413-414 
neurotransmitter transpon, 13-14 
oncogenesis and, 403-404 
position-dependent, 187-188 
post-transcriptional regulation, 120-122 
protein-DNA interaction, 427-429 
retroviruses, 99-100 
segmentation, 74 
steroid hormones, 347-348 
tissue-specific hormonal regulation, 9-10 
trans-activating proteins, 451-452 
visual pigments, 319-320 
"Gene gating," intercellular protein traffic, 49-50 
Gene mapping 
complex genomes, 62 
genome, xl 
human molecular genetics and, 142-144 
protein structure and folding, 139-140 
retroviral replication and, 60-62 
Gene regulation 
animal cells, 323-324, 451-452 
cell structure and, xxvi, xxx 
509 
