Index 
Gene regulation {continued) 
DNA-binding proteins, xxxv, xxxvii 
genetic disease and, xxxix 
growth factors, 441 
immunodeficiency, 355 
MyoD gene, 461-462 
segmentation and pattern formation, 72- 74 
Gene targeting, 71 
Gene therapy 
inborn errors of metabolism, 27 1-272 
inherited diseases, 75- 76 
See also Somatic gene therapy 
Genetic disease 
cancer as, 269-270 
gene therapy for, 487-488 
gene tracking studies, 89-90 
globin gene expression, 231-232 
hematopoietic cells, 335-336 
identification and correction, 75- 76 
mammalian development, 345-346 
molecular studies, 31-32 
Genetics 
experimental studies in, xxxv-xli 
structural studies, xxxv-xli 
Gene transfer 
inborn errors of metabolism, 271-272 
somatic gene therapy, 481 
"Gene trapping," recessive gene inactivation, 26 
Genome 
complexity, xxxv, xxxvii 
gene mapping, xl 
mammalian cell development, xxvi 
sequencing, technologies for, 83-84 
Geranylgeranylated proteins, cell regulation, 167 
Germ cells, recombination, 153-154 
Germline determination, in Drosophila, 277-278 
Glial cells 
couch potato gene expression, 35-36 
synaptic transmission and, // 
Globin genes, genetic disease and, 231-232 
a-Globins, gene expression, 285-286 
Glomerular basement membrane (GBM), in genetic disease, 
365 
Glucagon, gene expression, 182-184 
Glucoconicoids 
gene expression, 347-348 
regulatory network, molecular mechanisms, 127-128 
Glucose-6-phosphate dehydrogenase (G6PD) deficiency, 
factor VIII and, 165-166 
GLUT2 protein, 34 
GLUT4 protein, 34 
Glutamate receptors, synaptic transmission, 204 
Glutathione reductase (GR), functions, 253-254 
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), 
tissue-specific hormonal regulation, 9-10 
Glycoproteins 
biological membranes, 475 
gp63, in Leishmania parasites, 1 17 
internalization and degradation, 266 
intracellular transport, 265-266 
T cell surface, 289-290 
Glycosaminoglycan (GAG) chains, transforming growth 
factors, 301-302 
Glycosyl phosphatidylinositol (GPI), T cell activation, 
55-56 
Glycosyltransferases, mammalian development, 293-294 
GMP-140 protein, neutrophile adhesion, 294 
GOBP (general odorant-binding proteins), 283-284 
Golgi apparatus 
mammalian cell development, xxvii 
protein synthesis, xxx-xxxi 
Goodpasture syndrome, molecular genetics of, 365 
gp63 glycoprotein, Leishmania parasites, 117 
G proteins 
adrenergic receptors, 273-275 
hormonal signal transduction, 422 
neurotransmission and, Iv 
olfaction mechanisms, 363-364 
signaling mechanisms, 129-130 
signal transduction, 205-206, 247-248 
visual pigments, 319-321 
Granule membrane protein- 140 (GMP-140), 32 
Granulocyte colony-stimulating factor (G-CSF), 
hematopoietic stem cells, 37-38 
Growth cones, neuronal recognition and, 171-173 
Growth control, genetic analysis, 155-156 
Growth factor 
cell proliferation, 479-480 
genomic response, 317-318 
Growth factors 
gene regulation, 441 
hormonal signal transduction, 422 
transcription, 495-496 
Growth hormone receptor (GHR), dwarfism and, 142-144 
GTPase-activating proteins (GAPs), neurofibromatosis type 1 
(NFl), 472-474 
Guanylyl cyclase, 151-152 
Gyrate atrophy, metabolic pathways, 457-458 
H19 gene, embryogenesis, 449-450 
H-2 molecule, germ cell recombination, 153-154 
Hearing, ion channel activation and, 95-96 
Heart function 
clot formation mechanisms and, 126 
voltage-sensitive potassium channels, 217-218 
Heat-shock proteins 
functions, 287-288 
membrane and secretory proteins, 159-160 
protein 60 (hsp60), in vivo folding, 201-202 
Heavy-chain genes 
immunoglobulins, 229-230 
T cell receptors, xlii, xliv, xlvii 
"Helix dipole" effect, engineering proteins, 303-305 
Helix-helix association and stability, protein structure, 
65-66 
Helix-loop-helix proteins, myogenesis, 461-462 
Helper T cells 
functional heterogeneity, 57-58 
lymphoid cell growth and development, 445-446 
lymphokine secretion, xlii-xliii 
ontogeny and specificity, 43-44 
receptor diversity in, 24 
Hemagglutinin (HA) 
autoimmune model, 159-160 
glycoprotein mechanisms, 475 
Hemagglutinin-neuraminidase (HN) glycoprotein, 264-266 
Hematopoiesis 
growth control, 405-406 
lymphocyte gene expression, 413-414 
Hematopoietic stem cells 
genetic manipulation of, 37-38 
growth-regulating genes, 477-478 
hemoglobinopathies and, 335-336 
life history, 467-468 
molecular genetics, 335-336 
Hemoglobin 
gene regulation, xxxviii 
sickle cell anemia, xxxviii-xxxix 
switching, genetic disease and, 90 
Hemoglobinopathies, hematopoietic cells, 335-336 
Hemophilia A, molecular genetics of, 165-166 
Hepatitis B virus, mammalian development, 345-346 
Hepatitis delta antigen (HDAg), replication and 
pathogenesis, 257-258 
510 
