Index 
Hepatitis delta virus (HDV), replication and pathogenesis, 
257-258 
Hereditary persistence of fetal hemoglobin (HPFH), 90 
Heterochromatin, chromosome organization, 193-194 
Hippocampus 
memory cell studies, 233-234 
neurobiology, 399-400 
synaptic neuromodulation, 435-436 
voltage-sensitive potassium channels, 217-218 
Histocompatibility, molecular genetics of, 79-80 
Histocompatibility molecules 
genetics, structure, and function, 133-134 
germ cell recombination, 153-154 
glycoproteins, 475 
immunological tolerance and, 52 
molecular genetics, 79-80 
Histone proteins, gene expression, 189-190 
HIV. See Human immunodeficiency virus (HIV) 
HLH462 protein, growth factor response, 317-318 
HMG-COA reductase, macromolecule structure, 109-110 
HNF transcription factor, endodermal and hepatocyte 
differentiation, 98 
hnRNP proteins, post-transcriptional regulation, 120-122 
Holoenzymes, DNA replication, 331-332 
Homeobox genes 
embryonic kidney, 295-296 
heart development, 295 
target genes, 296 
Homeodomain-DNA complexes, crystal structures, 339 
Homeodomain proteins 
DNA-binding specificity, 115-116 
Drosophila development, 379-380 
gene activation, 374 
transcription, 114-116 
segmentation and differentiation, 29-30 
structural studies with, Itx 
Homeotic genes 
Drosophila development, 379-380 
segmentation and differentiation, 29-30 
Homologous recombination, gene targeting and, 71 
Hormone receptors 
molecular analysis of, 315-316 
steroid and thyroid, 127-128 
Hormones 
biology of, in health and disease, 273-275 
calcium-mediated, 129-130 
signal transduction, 420-422 
"Housekeeping" proteins, complement system, 21-22 
Hox genes, gene targeting, 71 
W* symport, lactose permease, 227-228 
Human developmental genetics, 25-26 
Human immunodeficiency virus (HIV) 
gene regulation, 355 
HIV- 1 , T cell growth and, 177-1 78 
HfV-1 and HIV-2, gene expression regulation, 99 
protein-DNA interaction, 427-429 
receptor structure, 185 
retroviral gene expression, 313-314 
T cell surface glycoproteins, 289-290 
transcriptional activation, 177-178 
Human T cell leukemia viruses (HTLV-I and HTLV-II) 
gene expression regulation, 99 
T cell growth and, 177-178 
T cell surface glycoproteins, 289-290 
trans-regulation of gene expression, 177-178 
Humoral immune response, helper T cells, xlii 
hunchback (hb) gene 
Drosophila development, 1 14- 116 
morphogen gradients, 437 
Huntington disease (HD) 
gene tracking, 89-90 
RFLP studies of, Ivi 
6-Hydroxyl-l ,6-dihydropurine ribonucleoside (HDPR), 
structure and function, 360-362 
Hyperkalemic periodic analysis, 95-96 
Hypertension, steroid hormone gene expression, 348 
Hypertriglyceridemia, LPL deficiency and, 262 
Hypomethylation, malignant transformation and, 131-132 
Hypoxanthine guanine phosphoribosyltransferase (HPRT) 
Lesch-Nyhan syndrome, 75-76 
YAC library, 334 
Imaginal discs, pattern formation and, 74 
Immune complex-mediated disease, complement receptors, 
195-196 
Immune response 
components of, xlii-xliii 
function and tolerance, 136-138 
molecular structural studies, 45-46 
parasite evasion of, 117-118 
Immune system 
components of, xlii 
development of, 91-92 
leprosy, 51-52 
mammalian development, xlv, xlvii 
receptor diversity in, 23-24 
structural studies, xli-l 
Immunoblotting, voltage-sensitive potassium channels, 
217-218 
Immunoglobulin 
autoimmune and self-tolerance mechanisms, 174-176 
B cell development, 411 
development and function, 453-454 
differentiation, 111-112 
gene expression and, 179-180 
genetic studies, 329-330 
heavy-chain gene, 229-230 
lymphocyte gene expression, 413-414 
protein structure and folding, 140 
Immunoglobulin A (IgA), immune system development, 
91-92 
Immunoglobulin M, mammalian development, xlv, xlvii 
Immunogold electron microscopy, oncogenesis and gene 
expression, 403-404 
Inborn errors of metabolism, molecular genetics of, 271-272 
Infection, self/non-self discrimination, 221-222 
Infectious disease, pathogenicity studies, 387-388 
Inflammatory T cells, functional heterogeneity, 57-58 
Influenza virus 
glycoprotein structure, 475 
structure and replication, 264-266 
Inositol 1 ,4,5-trisphosphate (IP3) 
calcium channels, 69 
signaling mechanisms, 129-130 
Insertion mutations 
couch potato gene, 35-36 
voltage-gated ion channels, 7-8 
In situ hybridization 
couch potato gene studies, 35-36 
eukaryotic chromosome structure, 394-396 
gene mapping, 142-144 
Instructional hypothesis, refutation of, xlvii 
Insulin 
molecular mechanisms, 47-48 
production and actions, 423-424 
receptors, 423-424 
structure and function, 123-124 
tissue-specific hormonal regulation, 9-10 
translational regulation, 485 
Insulin-like growth factors, 423-424 
Insulinotropic peptides, 184 
Insulin-responsive element A (IRE-A), tissue-specific 
hormonal regulation, 9-10 
Integrase, retroviral replication, 60-62 
511 
