Index 
molecular diflferentiation mechanisms, 111-112 
neoplasia development and, 249 
receptors, in immune response, xlii 
signal transduction, 351 
surface antigens, 389-390 
Lymphoid system 
cell growth and development, 445-446 
malignancies, immune system development, 91-92 
Lymphokines 
antibody generation, 12 
genetics of cancer and, 269-270 
helper T cell secretion, xlii-xliii 
Lysosomes, mammalian cell development, xxxi 
a-Lytic protease, structural studies, 4, 6 
genes, histocompatibility antigens and, 133-134 
Macromolecules 
assembly mechanisms, 185-186 
interactions, 303-305 
structural studies, 4-6 
three-dimensional structure, 109-110 
x-ray crystallography, Ivii 
Macrophages, immune system, xlii 
Major histocompatibility complex (MHC) 
antigen presentation, 103-104 
class I antigen presentation, 44 
immune system, xlvii 
molecular genetics, 79-80 
self-tolerance, 136-138 
T lymphocytes 
antigen receptor, 464-466 
foreign antigen recognition, 105-106 
ontogeny and specificity, 43-44 
structural biology, 369-370 
surface glycoproteins, 289-290 
Major outer membrane protein (MOMP) , antigen 
presentation, 104 
Malignant transformation, sequence of events in, 131-132 
Mammalian development 
autoantibody probes, 425-426 
disease and, 345-346 
embryogenesis, 449-450 
gene expression and, 189-190 
genetic control of, 25-26 
genetics and, 25-26 
glycosyltransferases, 293-294 
immune system, xlv, xlvii 
neuronal cells, 15-16 
sex chromosomes, 401-402 
X and Y chromosomes, 342-344 
See also Transgenic models 
mastermind gene, Drosophila neurogenesis and, 20 
"Master regulatory genes," neural development and, 
219-220 
Maternal -effect genes 
cell fate, 353-354 
Drosophila pattern formation, 277-278 
position-dependent gene expression, 187-188 
Maternally transmitted antigen (Mta) 
genetics, structure, and function, 133-134 
T lymphocyte biology, 3 70 
Maturity-onset diabetes of the young (MODY) 
molecular genetics of, 33-34 
See also Diabetes mellitus 
mb- 1 gene, lineage- and stage-specific expression, 180 
M channel, nerve cell electrical activity, 2 
meander tail ( mea) gene, mammalian cerebellum 
development, 190 
Mell4/Leu8, neutrophile adhesion, 294 
Membrane lipids, cell regulation, 167 
Membrane proteins 
diabetes, genetics and, 34 
helix-helix association, 65-66 
synaptic function and, 13-14 
Membrane transport proteins, lactose permease, 227-228 
Memory 
cell studies, 233-234 
T cell differentiation and activation, 55-56 
Meningiomas, growth control, 155-156 
Messenger RNA. See mRNA 
Metallothionein (MT) promoter, cholecystokinin regulation, 
146 
Metamorphosis, molecular basis, 447-448 
Methyl-malonyl CoA mutase (MCM), inborn errors of 
metabolism, 271-272 
Mevalonic acid, cell regulation, 167 
Microfilaments, in cytoskeleton, xxxi 
Microtubules, in cytoskeleton, xxxi 
Mitochondria 
in vivo folding, 201-202 
mammalian cell development, xxvii, xxxi 
T lymphocyte structure, 370 
Mitosis 
cell cycle studies, 27-28 
CSF- 1 -responsive genes, 406 
entry checkpoint, 297-298 
replication and, xxxi 
retroviral replication, 60-62 
Molecular dynamics (MD), protein function, 253-254 
Molecular recognition 
cell activity, lix 
cell structure, xxvi 
eukaryotic gene regulation and, 67-68 
Molecular replacement, x-ray crystallography, 65 
Moloney murine leukemia virus 
hematopoietic stem cells, 37-38 
receptor functions, 101 
reverse transcriptase, RNase H and, 192 
Morphogenesis, genetic control, 239-240 
Morphogen gradients, Drosophila body pMtems, 437-438 
M phase, in cell cycle, 27-28 
M-phase factor (MPF), 297-298 
mRNA (messenger RNA) 
heat-shock proteins, 287-288 
mammalian cell development, xxvi, xxix-xxx 
post-transcriptional regulation, 120-122 
RNA polymerase II, 93-94 
RNA transcription, xxxv, xxxvii 
splicing, RNA behavior, 371-372 
translational regulation, 485 
mRNP proteins, post-transcriptional regulation, 120-122 
Multiple-drug resistance (MDR), metabolic pathways, 
457-458 
Multiplexing, for DNA sequencing, 157-158 
Multiplex sequencing, of genomes, 83-84 
Multiwavelength anomalous diffraction (MAD), 
selenomethionyl protein, 191 
Murine leukemia virus (MLV), retroviral replication, 60-62 
Muscle 
contraction, molecular analysis of, 315-316 
neuromuscular development, 493-494 
Muscular dystrophy 
cloning and, Iv 
genetic correction of, 75- 76 
molecular genetics of, 251-252 
molecular pathogenesis, 69-70 
See also Becker and Duchenne muscular dystrophy 
Mutant selection, ion channel function, 491 
Mutations 
genetic disease and, xxxix 
hemophilia A and, 165-166 
513 
