Index 
Myasthenia gravis, acetylcholine function and, It 
Mycobacteria 
engineered avirulent mutants, 214-216 
immunity and pathogenesis, 51-52 
Myeloid cells, growth control, 405-406 
MyoD gene, myogenesis, 461-462 
Myosin heavy chain (MHC) 
familial hypertrophic cardiomyopathy (FHC), 397 
transc-fiption, 315-316 
Myosin proteins, ion channel activation and, 95-96 
Myristoylated alanine-rich C kinase substrate (MARCKS) 
protein, 48 
nac (neurally altered carbohydrate) gene, visual system 
development, 237-238 
Nectins 
cell adhesion, 207-209 
See also Fibronectins 
Nematode 
development, 197-199 
molecular genetics, 433-434 
nervous system development, Iv 
Neoplasia, lymphocyte development and, 249 
Nerve cells 
electrical activity, 1-3 
neuromuscular development, 493-494 
structural studies in, / 
Nerve growth factor (NGF) 
neuroimmunology, 349 
neuronal development, 15-16 
transcription, 495-496 
tumorigenesis, 63-64 
Nerve impulses. See Action potentials; Synapses 
Nervous system, neuromuscular development, 493-494 
Nested genes 
chromosome organization and, 193-194, 473-474 
metamorphosis, 447-448 
Neural reflexes, components of, //', liii 
Neurobiology, molecular engineering and, 455-456 
Neurofibromatosis type 1 (NFl) 
gene identification, 89-90, 472-474 
YAC library, 333-334 
Neurogenesis 
cell interactions, 18-20 
Drosophila visual system, 430-432 
olfaction mechanisms, 363-364 
Neuromodulation, 435-436 
Neuromuscular disease 
components of, //, liii 
molecular genetics of, 251-252 
Neuronal development, cell fate, 15-16 
Neuronal recognition 
Drosophila visual system, 430-432 
molecular genetics of, 1 71- 1 73 
Neuron doctrine, components of, / 
Neurons 
extracellular matrix, 367-368 
functions of, / 
second messenger pathways, 391-392 
structure, li-liii 
types of, li-lii 
Neuropeptides, processing and packaging, 384-386 
Neuroscience, structural studies in, l-lvi 
Neurotransmitters 
calcium channels and, 407-408 
molecular mechanisms, 129-130 
release mechanisms, 439-440 
synaptic neuromodulation, 435-436 
synaptic transmission, li, 203-204 
transport, gene expression, 13-14 
ninaA gene, visual transduction, 497 
N-myc genes, antibody generation, 12 
Nodes of Ranvier, ankyrin, 39-40 
Non-insulin-dependent diabetes mellitus (NIDDM) 
molecular genetics of, 33-34 
See also Diabetes mellitus 
Nonmuscle myosin light-chain kinase (nmMLCK), calcium 
physiology, 459-460 
nos gene, morphogen gradients, 437 
Notch gene 
Drosophila neurogenesis and, 19-20 
neuromuscular development, 493-494 
Notochord, nervous system development, 224-226 
Nuclear envelope, eukaryotic chromosome structure, 396 
Nuclear factor of activated T cells (NFAT), T lymphocyte 
activation and differentiation, 97-98 
Nuclear magnetic resonance (NMR) 
extracellular matrix biology, 53-54 
protein structure and folding, 139-140 
structural biology and, lix, 65-66 
Nucleolus, mammalian cell development, xxvi-xxvii 
Nucleus, mammalian cell development, xxvi-xxvii 
OAT enzyme, metabolic pathways, 457-458 
Obesity, molecular basis for, 145-146 
ob/ob genes, obesity and, 145-146 
Oct-2 protein, B cell development, 411 
Olfaction 
molecular biology of, 23-24 
second messenger system, 363-364 
tissue-specific snRNP protein, 283-284 
Oligosaccharides, glycosyltransferases, 293-294 
OMGP genes, neurofibromatosis type 1 (NFl), 472-474 
Ommatidia 
Drosophila visual system, 430-432 
visual system development, 375-376 
Onchocerciasis, immune evasion and, 118 
Oncogenes 
animal cell gene regulation, 451-452 
cell cycle and, xxxiv 
gene expression and, 403-404 
Opsonization, in complement system, 21-22 
Organelles, mammalian cell development, xxxi 
Ornithine transcarbamylase (OTC) deficiency, 75 
orthodenticle (otd) gene, Drosophila development, 
114-116 
OTFl regulatory protein, gene expression, 189-190 
Outer-surface protein A (OspA), immune response and, 
136-138 
Oxytricha, telomere structure, 77-78 
Pair-rule patterns, gene segmentation and, 73-74 
Papillomaviruses, types 16 and 18, 259-260 
Paramyxoviruses, structure and replication, 264-266 
Parasites, immune evasion by, 117-118 
Pattern formation 
central nervous system, 224-226 
in Drosophila, 277-278 
limb development, 86-88 
visual system, 430-432 
egg genetics, 418 
mammalian development, xxvi-xxx 
Patterson correlation coefficient, molecular replacement, 65 
Peptides 
ANP and, 151-152 
antigens, T lymphocyte biology, J 70 
period ( per ) gene 
biological rhythms in Drosophila, 493-494 
RNA processing, 371-372 
Peripheral nervous system (PNS) development in 
Drosophila, 35-36 
gene regulation, 219-220 
Peripheral neuroepithelioma, cholecystokinin regulation, 
146 
514 
