Index 
Peroxisome membrane protein (PMP), metabolic pathways, 
457-458 
Pertussis toxin, signal transduction, 205-206 
Phagocytic cells, Legionella growth in, 212 
Phase determination studies, structural biology and, Ivii 
Phenotypes, cell-cell interactions and, Iv 
Phenylalanine hydroxylase (PAH), gene therapy, 487-488 
Phenylketonuria (PKU), gene therapy, 487-488 
Pheromone-binding protein (PBP), 283-284 
Philadelphia chromosome, growth regulation, 483-484 
Phosphate transport, protein structure and function, 
360-362 
Phosphatidic acid (PA), molecular mechanisms, 130 
Phosphatidylcholine (PC), molecular mechanisms, 130 
Phosphatidylinositol 
polypeptide growth factors, 357-358 
signaling mechanisms, 129-130 
Phosphatidyl-inositol 4,5-bisphosphate (PIP2), signaling 
mechanisms, 129-130 
Phospholipase A2 (PlAj), cellular regulation, 409-410 
Phosphoprotein phosphatase, molecular mechanisms, 
203-204 
Phosphorylation 
EGF receptor function, 107-108 
post-transcriptional regulation, 120-122 
retroviruses, 99-100 
Phosphoryrosine, synaptic transmission, 203-204 
Photochemistry, molecular engineering and, 455-456 
Photoreceptor, visual system development, 376 
Photosynthesis, DNA photolyase, 110 
Phototransduction 
molecular genetics, 497 
retinal rods and cones, 489-490 
signal transduction, 205-206 
Pit-1 protein, gene activation, 374 
Plasma cells, immune response, xlii, xlvii 
Plasma membranes, cell structure, xxxii 
Plasminogen activator inhibitor, blood coagulation and, 
162-164 
Platelet-derived growth factor (PDGF) 
cell fate, 353-354 
cell proliferation, 479-480 
Pleiotropic mechanism, gene expression, 189-190 
Poliovirus, RNA genetics, 245-246 
Poly(A) addition sites 
alternative splicing, 316 
gene regulation, 324 
Polymerase chain reaction (PGR) 
Down syndrome analysis, 255-256 
dystrophin analysis, 252 
embryonic stem cells, 415-416 
fragile X chromosome studies, 76 
gene mapping, 144 
germ cell recombination, 153-154 
hematopoietic stem cells, 37-38 
large-scale DNA, 333-334 
RNA genetics, 245-246 
T lymphocyte function, 299-300 
Polypeptide growth factors, mechanism of, 357-358 
Polypeptide hormones 
gene regulation in, 182-184 
molecular mechanisms, 47-48 
Polypyrimidine binding protein (PBP), alternative splicing 
and, 316 
Population dynamics, of metabolic disorders, 487-488 
"Position effects," chromosome organization, 193-194 
Postsynaptic cells, gene expression, 13-14 
Post-transcriptional regulation, gene expression, 120-122 
Potassium ion channels 
alternative splicing, 316 
islet hormone evolution, 423-424 
nerve cell electrical activity, 1-3 
peptide neurotoxin probes, 309 
structure-function relations, 309-310 
voltage-activated, 491 
POU box, B cell development, 411 
POU-domain gene family, gene activation, 374-375 
pre-B lymphocytes, life history, 467-468 
Precursor cells, neuronal development, 15-16 
pre-mRNA 
autoantibody probes, 425-426 
RNA behavior, J 71-3 72 
Prenatal diagnosis 
globin gene expression, 231-232 
metabolic disorders, 487-488 
Prepattern genes, neural development and, 219-220 
Presynaptic cell, gene expression, 13-14 
proboscipedia gene, 239-240 
Proinsulin, 423-424 
Promoter cells, immunoglobulin heavy-chain gene, 229-230 
Promoter-specific regulators, transcription, 451-452 
Promoter traps, developmental genetics, 415-416 
Protein 
folding, 139-140, 242-244 
functional studies, 253-254 
intracellular transport, 381-383 
membrane, 159-160 
secretory, 159-160 
signal transduction, 420-422 
structural studies of, Ivii 
structure of, xxvi 
Protein C, blood clot prevention and, 125-126 
Protein-DNA interaction 
gene regulation, 427-429 
lymphocyte differentiation, 303-305 
structural studies of, Ivii 
Protein folding 
biophysical genetics, 139-140 
intermediates in, 242-244 
in vivo studies, 201-202 
lymphocyte differentiation, 303-305 
macromolecular recognition, 242-244 
membrane and secretory proteins, 160 
Protein kinase 
calmodulin-regulated, 459-460 
cell cycle, xxxii 
M phase, 27-28 
post-transcriptional regulation, 122 
synaptic transmission, 203-204 
Protein kinase A (PKA) 
ion channel regulation, 469-471 
second messenger pathways, 391-392 
synaptic neuromodulation, 435-436 
Protein kinase C (PKC) 
insulin mechanisms and, 48 
ion channel regulation, 469-471 
memory cell studies, 233-234 
second messenger pathways, 391-392 
signaling mechanisms, 129-130 
Protein phosphorylation 
EGF receptor function, 107-108 
post-transcriptional regulation, 120-122 
retroviruses, 99-100 
synaptic transmission, 203-204 
Protein S, blood clot prevention and, 125-126 
Protein synthesis 
insulin mechanisms and, 47-48 
intracellular trafficking, xxx-xxxi 
retroviral infection, 101 
translational regulation, 485 
Protein tyrosine kinase 
cell fate, 353-354 
EGF receptor function, 107-108 
insulin receptor studies, 123-124 
515 
