Index 
Protein tyrosine kinase {continued) 
lymphocyte signaling, 351 
T cell surface glycoproteins, 289-290 
tumorigenesis, 63-64 
visual system development, 376 
Proton pumps, neurotransmitter release, 439-440 
Proto-oncogenes, embryogenesis, 327-328 
Provirus integration, retroviral replication, 60-62 
P system, in vision systems, 311-312 
Purkinje cells, ankyrin deficiency and, 40 
Qa genes, germ cell recombination, 154 
Quiescent cells, cell cycle, 298 
Reaction centers (RCs), macromolecule structure, 109-110 
Receptor-ligand interaction, engineering proteins, 303-305 
Receptors 
cell structure, xxxii 
functional diversity of, 23-24 
HIV, 185 
macromolecular assemblies, 185- 186 
Recessive genes, conditional inactivation, 26 
Recombinant BCG, as multivaccine vehicle, 52 
Recombinant DNA technology, xxxv 
Recombination 
Down syndrome analysis, 256 
germ cells, 153-154 
protein-DNA interaction, 427-429 
"Recombination constructs," B and T lymphocytes, 11-12 
Red and green color blindness, factor VIII and, 165-166 
Red cells (erythrocytes) 
growth control, 405-406 
membrane proteins, globin gene expression, 231-232 
Regulatory molecules, neuronal development, 15-16 
Replication 
cell cycle studies, 27-28 
DNA sequencing and, xxxv-xxxvi 
mechanisms, 331-332 
protein-DNA interaction, 427-429 
ribonuclease H, 191-192 
Restriction fragment length polymorphisms (RFLPs) 
gene inactivation, 131-132 
gene mapping, xl 
Huntington's disease, Ivi 
Lowe's syndrome, 326 
mammalian cerebellum development, 190 
molecular basis of obesity and, 145-146 
Retina 
choroideremia, molecular genetics, 325 
development, 375-376 
gyrate atrophy, metabolic pathways, 457-458 
neural foundations, 311-312 
pigment molecular biology, 319-321 
insertional mutagenesis, 337-338 
phototransduction, 489-490 
Retinitis pigmentosa, gene mutations, 320 
Retinoic acid 
neuronal recognition, 431-432 
receptor response pathway, 127-128 
Retinoids 
nervous system development, 224-226 
X receptors (RXR), response pathways, 127-128 
Retroviral infection 
gene expression, 99-100 
mechanisms of, 101-102 
Retroviral vector, hematopoietic stem cells, 37-38 
Retroviruses 
gene expression, 313-314 
gene regulation, 99-100 
replication, 60-62 
Rett syndrome, gene mapping, 143-144 
Rev-erbAa gene family, thyroid hormones, 82 
Reverse transcriptase, RNase H and, 191-192 
Rev proteins 
gene expression regulation, 99 
response elements (RRE), gene expression regulation, 100 
Rex protein 
response element, 1 78 
trans-regulation of HTLV-I gene expression, 1 78 
Rheumatoid arthritis, T lymphocyte function, 299-300 
Rhodopseudomonas viridis, macromolecule structure, 
109-110 
Rhodopsin 
gene mutations, 320 
pigment molecular biology, 319-321 
insertional mutagenesis, 337-338 
phototransduction, 489-490 
Ribonuclease H, gene replication, 191-192 
Ribonucleoprotein complexes, post-transcriptional 
regulation, 120-122 
Ribonucleoprotein consensus sequences (RNP-CS), 
post-transcriptional regulation, 120-122 
Ribosome pausing, translational regulation, 485 
RIP60/RIP100 protein complex, gene expression, 189-190 
RMA-5 mutant cells, genetics, structure, and function, 133 
RNA 
catalysis, ribozymes and, 77-78 
chromosome end structure, 77-78 
genetics, 245-246 
pattern formation 
in Drosophila, 277-278 
position-dependent gene expression, 187-188 
processing and behavior, 371-372 
protein interaction, 120-122 
recombination, viral replication and pathogenesis, 
257-258 
splicing, autoantibody probes, 425-426 
RNA polymerase, gene transcription, xxvi, xxx 
RNA polymerase II, structure and function, 93-94 
Rods and cones 
phototransduction, 489-490 
signal transductions, 205-206 
Rous sarcoma virus, tumorigenesis and, 63-64 
R to C ratio, second messenger pathways, 391-392 
Saccharomyces cerevisiae. See Yeast 
SEC genes, protein translocation, 381-383 
Second messengers 
cell cycle, xxxii 
neuron pathways, 391-392 
olfaction mechanisms, 363-364 
synaptic transmission and, Iv 
Secretory process, protein transport, 381-383 
Segmentation 
antibody specificity, xlii, xliv 
genetic control of, 72- 74 
homeotic gene action, 29-30 
Selenium, thyroid hormone activation, 267-268 
Selenomethionyl protein, MAD structure, 191 
Self antigens, immune system, xlvi-xlvii 
Selfish DNA, mammalian cell development, xxvi 
Self/non-self discrimination 
immune response, xlii 
regulation, 221-222 
Self-tolerance 
mechanisms of, / 74- 1 76 
T lymphocyte function, 299-300 
Sequencing 
couch potato gene expression, 36 
gene cloning techniques, xxxix 
keratin expression and, 148-150 
LPL deficiency analysis, 262 
technologies, 83-84, 157-158, 333-334 
Serine-threonine kinase, memory cell studies, 234 
516 
