Index 
Serotonin (5-HT), synaptic function, 407-408 
Serrate gene, Drosopbila neurogenesis and, 20 
Set point hypothesis, 145 
seven- in- absentia (sina) gene, 376 
sevenless gene, visual system development, 375-376^ 
Severe combined immunodeficiency disease (SCID) 
blood cell formation, 478 
growth regulation, 483-484 
protein structure and function, 360-362 
Sex chromosomes 
mammalian development, 401-402 
See also X and Y chromosomes 
Sex combs reduced (Scr) gene, Drosopbila morphogenesis, 
239-240 
Sex determination 
mammalian sex chromosomes, 401-402 
X and Y chromosomes, 342-344 
"Sex-linked" traits, hemophilia A as, 165-166 
Sbaker proteins 
structure-function studies, 21 7-218 
voltage-gated ion channels, 7-8 
Shock, molecular pathogenesis, 41-42 
Short tandem repeat polymorphisms (STRs) , 75- 76 
Shuttle plasmids, vaccine research, 215-216 
Sickle cell anemia, globin gene expression, 231-232 
Side-chain cleavage enzyme (SCC), steroid hormones, 
347-348 
Signal recognition particle (SRP) 
nuclear organelles, 49-50 
protein translocation, 381-383 
Signal sequences, egg genetics, 418 
Signal transduction 
adrenergic receptors, 247-248 
cell fates, 353-354 
CSF-1 receptor, 405-406 
epidermal growth factor receptor and, 107-108 
ion channel activation and, 95-96 
lymphocytes, 351 
olfaction mechanisms, 363-364 
proteins, 420-422 
visual systems, 205-206 
Simian virus 40 (SV40). See SV40 
Single-channel reconstitution, ion channel proteins, 309 
Site-directed mutagenesis 
ion channel function, 491 
lactose permease, 227-228 
synaptic transmission, 204 
Skeletal muscle 
excitation-contraction coupling, 69-70 
troponin C genes, 280-282 
Skeletal muscle troponin C (sTnC), molecular analysis, 
280-282 
Skin 
keratin expression in, 148-150 
neuromuscular development, 493-494 
Skin-associated intraepithelial lymphocytes (s-IEL), T cell 
development and function, 453-454 
Skin diseases, keratin expression and, 148-150 
slit gene, Drosopbila neurogenesis and, 20 
Slow-binding enzyme inhibition 
eukaryotic gene regulation and, 67-68 
molecular recognition, 67-68 
Small nuclear ribonucleoprotein particles (snRNPs) 
gene expression, 425-426 
spliceosome assembly, 371-372 
tissue specificity, 283-284 
Smell. See Olfaction 
smgp25A protein, macromolecule structure, 110 
Sodium ion channels 
cell membrane regulation, 469-471 
nerve cell electrical activity, 1-3 
Somatic gene therapy 
blood cell formation, 478 
genetic disease, 481 
hematopoietic cells, 335-336 
inborn errors of metabolism, 271-272 
metabolic disorders, 487-488 
Somatostatin, gene expression, 182-184 
Southern analysis, tissue-specific hormonal regulation, 9-10 
Southwestern screening, tissue-specific hormonal 
regulation, 9-10 
Specificity 
antigen presentation, 103-104 
enzyme structure, 4-6 
snRNP protein, olfaction, 283-284 
steroid hormones, 347-348 
T lymphocytes, 43-44 
Spectrin, ankyrin-independent membrane attachment sites, 
40 
Spermatozoa, peptides, 151-152 
S phase, cell cycle studies, 27-28 
Spherocytosis, globin gene expression, 232 
Spinal muscular atrophy (SMA) mutations, molecular 
genetics of, 251-252 
Spinocerebellar ataxia, molecular studies, 32 
Spliceosome 
autoantibody probes, 425-426 
RNA behavior, 371-372 
Spores, cell fate, 169-170 
src genes, normal and oncogenic forms, 63-64 
Staphylococcal enterotoxin A (SEA) , T lymphocyte biology, 
370 
Stem cells. See Embryonic stem cells 
Steroid hormone 
gene expression, 347-348 
receptors, molecular mechanisms, 127-128 
Steroid receptor "superfamily," cellular regulation, 
409-410 
Steroid sulfatase (STS), X chromosomes, 402 
stripe gene, peripheral nervous system development, 36 
Structural biology 
computational techniques, 65-66 
genetic disease and, Ivi-lix 
Structural proteins, membrane skeletons, 39-40 
Substance P receptor (SPR), neuroimmunology, 349 
Substrate adhesion 
neuronal recognition and, 171-173 
RNase H and, 191-192 
Superantigens 
T cell receptors, 235-236 
T lymphocyte biology, 3 70 
Surface membrane, cell structure, xxxii 
SV5 paramyxoviruses, structure and replication, 264-266 
SV40 (simian virus 40) 
macromolecular assemblies, 185 
T antigen, 136-138 
Sympathetic neurons, cell fate, 15-16 
Synapses 
development and function, 384-386 
essential events of, xxxii-xxxiii 
functions of, / 
neuromodulation, 435-436 
Synapsins, neurotransmitter release, 439-440 
Synaptic potential 
neuromuscular function and, //, liii 
synaptic transmission and, //' 
Synaptic transmission 
biophysical mechanisms, li-liii 
molecular mechanisms, 203-204 
Synaptic vesicle, neurotransmitter release, 439-440 
Synaptophysin, neurotransmitter release, 439-440 
Synchrotron x-ray sources, structural biology with, Ivii 
517 
