Contents 
xix Foreword 
Purnell W. Choppin, M.D. 
xxi Trustees, Officers, and Principal Staff Members 
xxiii Medical Advisory Board 
xxiv Scientific Review Board 
xxvi Locations of Howard Hughes Medical Institute Laboratories 
xxix Introduction 
xxix Cell Biology and Regulation Program 
XXXix Genetics Program 
xlvi Immunology Program 
liv Neuroscience Program 
Ixi Structural Biology Program 
W. Maxwell Cowan, M.D., Ph.D. 
1 Electrical Activity of Nerve Cells 
Paul R. Adams, Ph.D. 
3 Three-Dimensional Macromolecular and Cellular Structure 
David A. Agard, Ph.D. 
5 Molecular Mechanisms of Ion Channel Function 
Richard W. Aldrich, Ph.D. 
7 Divergent Members of the SRY Family of Transcriptional Regulators 
Bind an Insulin-Responsive Element, IRE-A 
Maria C. Alexander-Bridges, M.D., Ph.D. 
9 Genetic Mechanisms Involved in the Generation of the 
Antibody Repertoire 
Frederick W. Alt, Ph.D. 
11 Control of Cell Fate During Vertebrate Neuronal Development 
David J. Anderson, Ph.D. 
13 Cell Fate Choices in the Nervous System and Elsewhere 
Spyridon Artavanis-Tsakonas, Ph.D. 
15 The Complement System 
John P. Atkinson, M.D. 
1 7 The Molecular Biology of Smell 
Richard Axel, M.D. 
19 Mammalian Developmental Genetics 
Gregory S. Barsh, M.D., Ph.D. 
21 Cell Cycle Control 
David H. Beach, Ph.D. 
Hi 
