Contents 
57 Computational Structural Biology 
Axel T. Briinger, Ph.D. 
59 Biophysical Studies of Eukaryotic Gene Regulation and 
Molecular Recognition 
Stephen K. Burley, M.D., D.Phil. 
61 Molecular Studies of Calcium Channels and the Dystrophin- 
Glycoprotein Complex 
Kevin P. Campbell, Ph.D. 
63 Gene Targeting 
Mario R. Capecchi, Ph.D. 
65 Genetic Control of Pattern Formation in Drosophila 
Sean B. Carroll, Ph.D. 
69 Human Disease Gene Identification and Correction 
C. Thomas Caskey, M.D. 
71 Enzymatic RNA Molecules and the Structure of Chromosome Ends 
Thomas R. Cech, Ph.D. 
73 Molecular and Cellular Physiology of Acute Inflammatory Cytokines 
David D. Chaplin, M.D., Ph.D. 
75 Hormonal Regulation of Gene Expression 
William W. Chin, M.D. 
77 Technologies for Genome-sequencing Projects 
George M. Church, Ph.D. 
79 Molecular Genetics of Limb Development in Drosophila 
Stephen M. Cohen, Ph.D. 
81 Tracking Genes That Cause Human Disease 
Francis S. Collins, M.D., Ph.D. 
83 Development of the Immune System 
Max D. Cooper, M.D. 
85 Structure and Function of RNA Polymerase II 
Jeffry L. Corden, Ph.D. 
87 Mechanically Activated Ion Channels 
David P. Corey, Ph.D. 
89 Genetic Regulatory Mechanisms in Cellular Differentiation 
Gerald R. Crabtree, M.D. 
91 The Mechanism of a Bacterial Transposition Reaction 
Nancy L. Craig, Ph.D. 
V 
