Introduction 
mosome replication, the genetic basis of embry- 
onic development, and the control of gene 
regulation, it also holds promise for an assault on 
the even more complex problems that confront 
those interested in human disease. Cancer has a 
clear genetic basis. Specific genes, generally those 
concerned with cell growth and gene regulation, 
have been shown to be involved in many different 
malignancies. Other disorders, such as heart dis- 
ease and hypertension, have clear genetic compo- 
nents. Even distressing behavioral disorders like 
manic depression and schizophrenia have a genetic 
basis that may offer important clues to their nature 
and perhaps, in time, to their treatment. 
The real power of the new genetics is that it 
Investigators in the Genetics Program 
Barsh, Gregory S., M.D., Ph.D. 
Beachy, Philip A., Ph.D. 
Beaudet, Arthur L., M.D. 
Bell, Graeme I., Ph.D. 
Bellen, Hugo J., D.V.M., Ph.D. 
Belmont, John W., M.D., Ph.D. 
Brown, Patrick O., M.D., Ph.D. 
Capecchi, Mario R., Ph.D. 
Caskey, C. Thomas, M.D. 
Cech, Thomas R., Ph.D. 
Church, George M., Ph.D. 
Cohen, Stephen M., Ph.D. 
Collins, Francis S., M.D., Ph.D. 
Corden, Jeffry L., Ph.D. 
Cullen, Bryan R., Ph.D. 
Desiderio, Stephen V., M.D., Ph.D. 
Desplan, Claude, Ph.D. 
Donelson, John E., Ph.D. 
Duyk, Geoffrey M., M.D., Ph.D. 
Feinberg, Andrew P., M.D., M.P.H. 
Francke, Uta, M.D. 
Friedman, Jeffrey M., M.D., Ph.D. 
Geliebter, Jan, Ph.D. 
Gesteland, Raymond F., Ph.D. 
Ginsburg, David, M.D. 
Gitschier, Jane M., Ph.D. 
Henikoff, Steven, Ph.D. 
Norwich, Arthur L., M.D. 
Kadesch, Thomas R., Ph.D. 
Kan, Yuet Wai, M.D., D.Sc. 
Kaufman, Thomas C, Ph.D. 
Kunkel, Louis M., Ph.D. 
Kurnit, David M , M.D , Ph.D. 
Laimins, Laimonis A., Ph.D. 
Lalouel, Jean-Marc, M.D., D.Sc. 
Leder, Philip, M.D. 
Ledley, Fred D., M.D. 
Liebhaber, Stephen A., M.D. 
Lindquist, Susan L., Ph.D. 
allows investigators to approach these complex 
problems using a reductionist approach. If, for 
instance, a gene contributes to the development 
of a behavioral disorder, it is reasonable to as- 
sume that it also plays an important role in pro- 
gramming normal behavior. By identifying such 
genes and understanding the chemistry of their 
protein products, we should obtain important in- 
sights about the biological basis of behavior. 
Thus the ultimate promise of the new genetics is 
that it will help us to understand diseases that are 
not commonly thought of as being primarily ge- 
netic and, in doing so, it will tell us much about 
those biological processes that lie at the very core 
of our humanity. 
Lowe, John B., M.D. 
Malim, Michael H., Ph.D.* 
Nabel, Gary J., M.D. Ph.D. 
Nadal-Ginard, Bernardo, M.D., Ph.D. 
Nathans, Daniel, M.D. 
Nathans, Jeremy, M.D., Ph.D. 
Nevins, Joseph R., Ph.D. 
Nussbaum, Robert L., M.D. 
Olson, Maynard V., Ph.D. 
Or kin, Stuart H., M.D. 
Overbeek, Paul A., Ph.D. 
Page, David C, M.D. 
Palmiter, Richard D., Ph.D. 
Perrimon, Norbert, Ph.D. 
Reeders, Stephen T., M.D. 
Rosbash, Michael, Ph.D. 
Sakonju, Shigeru, Ph.D. 
Seidman, Jonathan G., Ph.D. 
Singh, Harinder, Ph.D. 
Soriano, Philippe M., Ph.D., D.Sc. 
Steitz, Joan A., Ph.D. 
Sternberg, Paul W., Ph.D. 
Sukhatme, Vikas P.. M.D., Ph.D. 
Taub, Rebecca A., M.D. 
Thummel, Carl S., Ph.D. 
Tilghman, Shirley M., Ph.D. 
Tjian, Robert, Ph.D. 
Valle, David L., M.D. 
Warren, Stephen T., Ph.D. 
Weintraub, Harold M., M.D., Ph.D. 
White, Raymond L., Ph.D. 
Williams, David A., M.D. 
Woo, Savio L. C, Ph.D. 
Young, Michael W., Ph.D. 
* This investigator was appointed after manu- 
scripts were submitted for publication. His re- 
search will be described in the next volume. 
xlv 
