Mechanism of Retrovirus Infection 
derstanding the host response to retrovirus infec- 
tion and also for understanding virus interference 
— the production by cells of retroviruses that are 
resistant to additional infection by the same virus. 
To investigate this problem, we are now examin- 
ing the behavior of MCAT proteins that contain 
mutations at the site of virus attachment. Our 
long-term goal is to understand the chemical 
basis of the virus-transporter interaction in suffi- 
cient molecular detail to design small molecules 
that can block virus binding and prevent 
infection. 
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