Biological Roles and Expression of Complement Receptors 
tant in gene regulation. We have determined that 
the receptor levels go up and down because the 
gene is turned on and off during development, 
we have identified functionally important do- 
mains and sites of protein interaction within the 
CR2 promoter, and we are clarifying the role of 
each site in CR2 expression and B cell matura- 
tion. These studies will increase our understand- 
ing of specific gene expression in B lymphocytes 
and further our knowledge of how to alter B cell 
phenotypes along pathways that might be more 
beneficial during certain disease states. 
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