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The commonest rhodopsin mutation among patients with autosomal dominant retinitis pigmen- | 
tosa has a substitution of the amino acid histidine for proline 23- Antibody-stained human opsin | 
(the apoprotein of rhodopsin), expressed by transient transfection in tissue culture cells, is i 
shown here. A: Wild-type opsin accumulates in the plasma membrane. B: The mutant opsin is \ 
predominantly in the endoplasmic reticulum. | 
From Sung, C. -H., Schneider, B.G., Agarwal, N., Papermaster, D.S., and Nathans, f. 1991. Proc I 
Natl Acad Sci USA 88:8840-8844. j 
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