Index 
abd-A gene, Drosophila development, 549 
ABL oncogene, lymphocyte growth regulation, 452-454 
Acetylcholine, neuronal function, Iv 
Acetylcholine receptor (AChR) 
ion channel function, 463-464 
neuronal function, Iv, lix 
achaete scute gene complex (AS-C), 12 
Acquired immune deficiency syndrome (AIDS) 
CD4 and CDS molecules, 182 
gene expression, cellular transcription, 285-286 
immune response and, lii-liii 
mycobacterial disease, 200-202 
retroviral replication, 53-54 
T cell development biology, 265-266 
Acrosome reaction, sperm physiology, 491-492 
a-Actinin, neuromuscular disease, 233-234 
Action potentials 
definition of, Iv 
generation in olfaction and, 332 
research on, 1-2 
Activin, transforming growth factor and, 275-276 
Adducin 
egg structure-function studies, 386 
spectrin skeleton assembly, 34 
Adenomatous polyposis coli (APC), 441-442 
Adenosine, neuromodulation, caffeine consumption, 
401-402 
Adenosine deaminase 
deficiency 
blood cell formation, 446 
gene therapy, 69- 70 
structure/function studies, 329-330 
Adenovirus 
gene expression control model, 369-370 
transcriptional regulation, oncogenesis, 293-294 
Adrenal cortex, steroid hormone gene expression, 317-318 
Adrenergic receptors 
molecular biology, 25/-252 
structure and function, lix, 229-230 
tVj-Adrenergic receptor, structure and function, 229-230 
/3-Adrenergic receptor kinase (/3ARK), 252 
(32-Adrenergic receptor, cellular biology, 230 
Adult respiratory distress syndrome (ARDS), in inflammation 
and metastasis, 40 
Affective disorders, neurological dysfunction and, Ix 
Agammaglobulinemia, immune system development and, 84 
agouti genes, mouse development and, 19-20 
Agrin 
molecular neuroimmunology, 319-320 
synaptic transmission, 355-356 
AIDS. 5ee Acquired immune deficiency syndrome 
Albinism, tyrosinase and, 307-308 
Aldose reductase, structure/function studies, 329-330 
Aldosterone, cardiovascular disease and, 244 
Allelic exclusion 
B cell development, 299-300 
immune response and, /// 
Allosteric enzymes, structural studies, 388 
al protein, DNA interactions, 309-311 
Alternative splicing, protein diversity and, 288 
Amblyopia, neurophysiology of visual systems, 284 
Amino acids 
protein structure, xxx 
transport, retroviral infections, 97-98 
Aminopeptidase A (APA), 84 
Animal cells 
example of, xxx-xxxi 
gene regulation, 293-294 
Ankyrin, structure, 34 
Ankyrins, plasma membranes, 33-34 
Antennapedia locus, morphogenesis, 223-224 
Anterior-posterior patterning, embryogenesis, 525-526 
Antibodies 
complement system, 15-16 
gene sequences and, xlviii, li 
lymphocyte difl'erentiation, 110 
molecular mimicry by, 110 
Antibody-antigen interactions, structure/function studies, 
329-330 
Antigens 
cytotoxic T cells, 37-38 
determinant, immune response and, li 
gene sequences and, xlix, li 
immune response and, xlvi, li-liii 
processing mechanisms, 93-94 
Antigen-specific receptors 
generation of, 351-352 
genetic mechanisms, 9-10 
Antiports, leukocyte homeostasis, 497-498 
Aplysia. cell biological studies of memory, 219-220 
Apolipoprotein E, chromosome structural studies, 4 
Apoptosis 
inflammatory cytokines, 73- 74 
visual systems, neurogenesis and, 398 
Arachidonic acid, phospholipids, 165-166 
Archaebacteria, protein folding, 189-190 
Atherosclerosis, platelet-derived growth factor (PDGF), 
447-448 
Atrial natriuretic peptides (ANPs), 151-152 
aWTw 7 attachment, transposition mechanism, 91-92 
Autoantibody probes. See also Small nuclear 
ribonucleoproteins (snRNPs) 
gene expression, 391-392 
Autoimmune disease 
biology of T cell development, 265-266 
CD4 T cell activation, 209-210 
complement system, 15-16 
immune response, 11, 136-138 
mechanisms, 171-172 
T cell function in, 273-274 
tissue-type plasminogen activator (t-PA), 157-158 
Autosomal dominant polycystic kidney disease (ADPKD), 
333-334 
Avian leukemia virus (ALV), 95-96 
Axenization, Entamoeba histolytica, 515-516 
Axon guidance 
neural development, 207-208 
structure and function, liv 
visual systems, neuronal cell recognition, 396-398 
B cells 
complement receptors, 185-186 
development, 9-10 
gene regulation, 379-380 
immune response, xlvi 
immune system development and, 83-84 
immunoglobulin heavy-chain gene control. 215-216 
immunological self-tolerance and autoimmunity, / 71- 1 72 
molecular regulation, 299-300, 415-416 
signal transduction pathways, 159-160 
B7 molecule, T cell activation, 209-210 
Bacterial toxins, protein crystallography, 521-522 
fcrt/- genetic sites, phage X, 501-502 
Bare lymphocyte .syndrome (BLS), 325-326 
Base pairing, DNA structure and, xxxix 
bed gene, transcriptional activation, 403 
BCG (bacille Calmette-Guerin) vaccine 
leprosy and tuberculosis immunity and pathogenesis, 
4 7-48 
mycobacterial disease, 200-202 
BCR/ABL protein, lymphocyte growth regulation, 452-454 
Becker muscular dystrophy 
gene identification and correction, 69 
533 
