Index 
Cell growth 
cell structure and, xxxv-xxxvi 
liver regeneration, 411-412 
Cell injury, inflammatory cytokines, 73-74 
Cell lineage, Caenorhabditis elegans development, 
187-188 
Cell migration, Caenorhabditis elegans development, 188 
Cell motility, defined, xxxv 
Cell regulation 
chemistry, 375-576 
phospholipids, 165-166 
Cell signaling, Caenorhabditis elegans development, 
187-188 
Cell-mediated immunity 
CD4-bearing T lymphocytes, 51-52 
research on, xlvi 
Cellular metabolism, peptide activation, 175-176 
Central nervous system (CNS), growth cone guidance and, 
169-170 
Centromere, position efi'ects, 184 
Cerebellum development, gene expression and cell cycle, 
179-180 
Cerebral cortex 
sensory representations, visual system, 367-368 
spatial information, 527 
Cervical cancer, papillomavirus molecular biology, 241-242 
c-Fos protein, transcription control, 470 
CGG repeat, fragile X syndrome, 431-432 
cGMP (cyclic GMP) 
phototransduction mechanism, retinal rods and cones, 
461-462 
second messengers and cell regulation, 151-152 
Chagas disease, kinetoplast genome, 378 
Chaperone genes, heat-shock proteins (HSPs), 261-262 
Charcot-Marie-Tooth disease, gene mapping, 141 
Chemical communication, sex pheromones, 257-258 
Chemotaxis, sperm physiology, 491-492 
Chloramphenicol acetyltransferase (CAT), 35-36 
Chloride channels 
cystic fibrosis transmembrane conductance regulator 
(CFTR), 439-440 
purification and reconstitution, 281-282 
Chloroplasts, protein translocons and, 45-46 
Cholecystokinin, molecular biology of, 143-144 
Cholera toxins, protein crystallography, 521-522 
Cholesterol, metabolism, 4 
Choroideremia, molecular genetics, 295-296 
Chromaffin cells, cell fate control, 11-12 
Chromatin 
cell cycle control, 21-22 
three-dimensional structure, eukaryotic chromosomes, 
362 
Chromosome 7, mapping in cystic fibrosis (CF), 531-532 
Chromosome puffs, metamorphosis, 417-418 
Chromosomes 
end structure, 71-72 
structure and function, position efl'ects, 183-184 
three-dimensional studies, 3-4 
eukaryotic chromosomes, 360-362 
unstable, position effects, 183-184 
Chylomicronemia syndrome, genetic studies of 
cardiovascular disease, 243-244 
Cilia, ion channel activation, 87-88 
Circular dichroism, extracellular matrix, 49 
c-jun gene, epidermal growth factor (EGF), 104 
Clathrin, Yersinia pseudotuberculosis, 197-198 
C-less permease, energy-transducing membrane proteins, 
213-214 
Clonal deletion, immune response and, // 
Clonal selection hypothesis, immune response and, // 
Cloning 
DNA, yeast artificial chromosomes (YACs), 303-304 
genetically related. Entamoeba histolytica, 515-516 
scorpion toxin receptor genes, 520 
c-myc gene 
epidermal growth factor (EGF), 104 
transcription control, 470 
Collagen, hereditary kidney disease, 333-334 
Colon cancer, APC gene and, 441-442 
Colony-stimulating factor (CSF), myeloid cell growth 
control, 371-372 
Colony-stimulating factor (CSF) 1 receptor (CSF-IR), 
371-372 
Colorblindness, X-linked disorders, 163-164 
Common variable immunodeficiency (CVID), 84 
Complement component C3, gene regulation, 185-186 
Complement receptor 2 (CR2), 185-186 
Complement system 
immune response and, lii-liii 
research on, 15-16 
Complementation-determining region (CDR), 101 
Computational modeling 
sensory representations, 367-368 
visual systems neurophysiology, 283-284 
Computer-aided drug design, protein crystallography, 
521-522 
Constant (invariant) domain, protein chains, xlvi 
a-Constant Spring (aCS), a-globin gene expression, 260 
Contractile protein genes, transcriptional regulation, 
287-288 
Co-receptors. See also CD4 and CDS molecules 
immune response and. Hi 
Coronavirus, replication and pathogenesis, 239-240 
couch potato {cpo) gene, peripheral nervous system 
development, 29-30 
Cro repressor protein, macromolecular interaction, 278 
c-src proto-oncogene, 383-384 
Cyclic nucleotide-gated channel (CNG), second-messenger 
ion channel regulation, 373-374 
Cyclins 
cell cycle control, 21-22 
G2 cyclins, 271-272 
Cyclosporin A, T cell activation and differentiation, 90 
Cysteinyl residues, energy-transducing membrane proteins, 
213-214 
Cystic fibrosis (CF) 
gene expression, chromosome 7 mapping, 531-532 
linkage analysis and, 81 
molecular studies of, 25-26 
somatic gene therapy, 449-451 
Cystic fibrosis transmembrane conductance regulator (CFTR) 
function and regulation, 439-440 
mapping in cystic fibrosis (CF), 531-532 
multidrug resistance, 499-500 
somatic gene therapy, 449-451 
Cytochrome b/c, complex, photosynthesis and respiration, 107 
Cytochrome P-450 enzymes, macromolecular structure, 108 
Cytokines 
CD4-bearing T lymphocytes, 51-52 
effector functions in immune responses, 513-514 
inflammation and, 73-74 
Cytoplasm, structure, xxxv 
Cytoskeleton 
cell adhesion and, 196 
host-pathogen interactions, 493-494 
structure, xxxv 
Cytotoxic T cells 
immune response and, xlvi 
recognition of, 37-38 
D-type cyclins, 371-372 
DCoH dimerization cofactor, genetic regulatory 
mechanisms, 8V-90 
Decay-accelerating factor, complement system, 16 
535 
