Index 
"Decoding code," mRNA, 155-156 
Deformed gene, Drosophila morphogenesis, 24 
Delayed-early (DE) genes 
growth factors, 289-290 
viral gene regulation, 279-280 
Deletion mutagenesis, cell fate control, 13-14 
Delta genes, cell fate control, 13-14 
Dendrites, structure and function, liv 
Density-sensing factor (DSF), differentiation and, 166-168 
Desensitization, epidermal growth factor (EGF), 328 
Developmental genetics, mutagenesis projects, 383-384 
Diabetes mellitus 
aldose reductase functions, 330 
immune tolerance, 136-138 
IRE-A DNA-binding protein, 8 
molecular genetics, 27-28, 143-144 
stiff-man syndrome and, 106 
tissue-type plasminogen activator (t-PA), 157-158 
type II, polygenic inheritance, 144 
Diacylglycerol (DAG) 
calcium-mediated hormones, 130 
sex pheromones, 257-258 
Diarrhea, guanylyl cyclase receptors, 152 
Dictyostelium discoideum, differentiation and, 166-168 
Differentiation 
developmental control of gene expression and, / 73 
genetic regulatory mechanisms, 89-90 
keratin expression, skin development, 146-148 
kidney cells, transcription factors, 407-408 
in lymphocytes, 109-110 
motor neurons, 211-212 
T cell recognition and, 101-102 
visual system development, 341-342 
DiGeorge syndrome, gene targeting and, 63-64 
Dihydropyridine receptor 
calcium channels, 409 
voltage-gated calcium channels, 61-62 
Disease genes. See Genetic disease 
Distal-less gene, limb development genetics, 79-80 
DNA 
breakage, bacterial transposition reaction, 91-92 
fingerprinting, gene mapping, xliv 
genome sequencing, 77 
probes, adenomatous polyposis coli (APC), 441-442 
repair, antibody genes, 9-10 
replication mechanisms, 301-302 
strand transfer, bacterial transposition reaction, 91-92 
structure of, xxxix-xl 
synthesis, cell cycle control and, 271-272 
DNA photolyase, DNA repair and, 107 
DNA polymerase III 
(3-subunit structural studies, 235-236 
replication mechanisms, 301-302 
DNA-binding proteins. See also Protein-DNA interaction 
Drosophila melanogaster, developmental genetics, 
349-350 
immunoglobulin heavy-chain gene control, 215-216 
structural studies, 309-311, 393-395 
transcription regulation, 421-422 
dorsal gene, signal transduction in B cells, 159-160 
Down syndrome, molecular analysis, 237-238 
Drosophila melanogaster 
axis formation and germline determination, 253-254 
behavior and neuromuscular development, 465-466 
cell adhesion and, 196 
cell fate control 
embryonic development, 13-14 
regulatory molecules, 12 
developmental genetics, 349-350 
egg structure-function studies, 385-386 
embryogenesis 
oncogenes, 297-298 
transcription control, 112-114 
eukaryotic chromosomes, three-dimensional structure, 
360-362 
growth cone guidance and neuronal development, 
169-170 
heat-shock proteins (HSPs), 261-262 
ion channels, molecular mechanisms, 5-6 
limb development genetics, 79-80 
morphogen gradients and pattern development, 403-404 
morphogenesis, genetic control, 23-24, 223-224 
neural development, 207-208 
neuronal function, lix 
voltage-sensitive channels, 205-206 
pattern-formation genes, 65-67, 507-508 
peripheral nervous system development, 29-30 
position effects, 183-184 
research with, xliv 
retinal cell-cell interactions, 471-472 
sensory transduction, 473 
signal transduction 
intercellular communication, 323 
visual systems, 193-194 
visual systems 
embryogenesis, 341-342 
pattern formation and neuronal cell recognition, 
396-398 
Drugs, receptors, molecular biology, 251-252 
Duchenne muscular dystrophy (DMD) 
dystrophin, 62 
gene identification and correction, 69-70 
molecular genetics, 233-234 
neuronal function, Ix 
Dysentery. See also Diarrhea 
Entamoeba histolytica variability, 515-516 
protein cr^'stallography, 521-522 
Dystroglycan, Duchenne muscular dystrophy (DMD), 62 
Dystrophin 
Duchenne muscular dystrophy (DMD), 62 
identification and correction, 69-70 
neuronal function, Ix 
research on, xliii 
Dystrophin-associated glycoproteins (DAGs), 62 
calcium channels, 61-62 
Dystrophin-related protein (DRP), neuromuscular disease, 
233-234 
ElA protein, gene expression, 369-370 
E2 transcription factor, cellular regulation, 375-376 
E74 gene, metamorphosis, 417-418 
Early B cell factor (EBF), gene expression and, 174 
EBERs, autoantibody probes, 392 
Ecdysone, metamorphosis, 417-418 
Egg cells, structure-function studies, 385-386 
Egg-laying hormone (ELH), neuropeptide processing and 
packaging, 355-356 
Egr gene family, kidney cell growth and differentiation, 
407-408 
Electron microscopy (EM), chromosome structure, 3-4 
Electrostatic interactions, ligand molecular recognition, 330 
Elliptocytosis, hemoglobin synthesis, 218 
Embryogenesis 
anterior-posterior patterning, 525-526 
oncogenesis in, 297-298 
Embryonic induction mechanisms, vertebrates, 269-270 
Embryonic stem (ES) cells 
anterior-posterior patterning, 525-526 
developmental genetics and, 20, 383-384 
Drosophila embryogenesis, 508-509 
mammalian memory, 423-424 
molecular studies of cystic fibrosis, 25-26 
Emery-Dreifuss muscular dystrophy, X chromosome, 
431-432 
Endocrine cells, synaptic vesicle traffic in, 105-106 
536 
