Index 
Endoplasmic reticulum (ER) 
cytotoxic T cells, 37-38 
protein translocons and, 45-46 
Endothelial cells 
blood clotting regulation, 344-346 
blood vessel function, 459-460 
in inflammation and metastasis, 39-40 
Endothelial leukocyte adhesion molecule- 1 (ELAM-1), 
39-40 
Endothelins, blood vessel function, 459-460 
engrailed {en) genes 
DNA-protein interactions, 309-311 
Drosophila morphogenesis, 23-24 
embryogenesis, 507-508 
anterior- posterior patterning, 525-526 
Enhancer genes 
peripheral nervous system development, 29-30 
viral gene regulation, 279-280 
Enhancer of split code, cell fate control, 13-14 
Entamoeba histolytica, variability in, 515-516 
Enteropathogenic bacteria 
molecular biology, 487-488 
pathogenicity studies, 357-359 
Enzyme specificity, chromosome structure, 3-4 
Epidermal growth factor (EGF) 
action mechanisms in, 327-328 
cell fate control, 13-14 
signal transduction of receptor, 103-104 
Epidermolysis bullosa simplex (EBS), 148 
Epigenetic changes, tumor-suppressor genes, 132 
Epinephrine, receptors for, 251-252 
Epithelial cells 
cystic fibrosis transmembrane conductance regulator 
(CFTR), 439-440 
papillomavirus molecular biology, 241-242 
Epitope, immune response, xlvi 
Epstein-Barr virus (EBV) 
autoantibody probes, 392 
complement receptors, 185-186 
familial hypertrophic cardiomyopathy (FHC), 363-364 
T cell function, 273- 274 
erbB oncogene, epidermal growth factor (EGF), 104 
Escherichia coli 
chromosome structural studies, 4 
enteropathic (EPEC), 357-359 
genome sequencing, 77 
protein-DNA interaction, 394-395 
transposition mechanism, 91-92 
E-selectin, glycosyl transferase molecular genetics and, 268 
ets genes, hematopoiesis genetics, 486 
Eukaryotic chromosomes, three-dimensional structure, 
360-362 
Excitation-contraction (E-C) coupling, 409 
Exocytosis, synaptic vesicle mechanisms, 106 
Exons, structure, xxx 
Extracellular matrix 
cell structure and, xxxvi-xxxvii 
molecular biology, 49 
neuron development, 335-336 
Factor VIII 
coagulation genetics, 161-162 
X-linked disorders, 163-164 
Familial hypercholesterolemia (FH) 
genetic studies of cardiovascular disease, 243-244 
somatic gene therapy, 449-451 
Familial hypertrophic cardiomyopathy (FHC), 363-364 
Fasciclin, growth cone guidance and, 170 
FBPase, intracellular protein transport, 353-354 
Fc receptors, cell surface recognition, 41-42 
Fibrinogen, tyrosine phosphorylation in platelets, 55-56 
Fibroblast growth factor (EGF) 
blood vessel formation, 448 
cell fate control, 11-12 
embryonic mouse development, gene targeting, 63-64 
macromolecular interaction, 278 
structural studies, 387-388 
tyrosine phosphorylation, 56 
Fibronectins, cell adhesion and, 195-196 
Finding the Critical Shapes, xix 
FK-506 immunosuppressants, 90 
Flavin-adenine dinucleotide (FAD), DNA repair and, 107 
Floor plate-specific genes, 211-212 
Fluorescence, molecular engineering, 426-428 
FMR l gene, fragile X syndrome, 431-432 
Follicle-stimulating hormone (FSH), gene mapping, 142 
Foreskin epithelial cells, papillomavirus molecular biology, 
241-242 
Fas genes, kidney cell growth and differentiation, 407-408 
Fragile X syndrome, 431-432 
gene identification and correction, 69-70 
Free-energy perturbation, structural biology, 58 
Free R value, NMR accuracy, 57-58 
Friend leukemia virus, hematopoiesis, 485-486 
From Egg to Adult, xix 
Fructose transport, molecular genetics of diabetes and, 28 
Fucosyltransferase, molecular genetics, 267-268 
Fused gene, mammalian development, 419-420 
G protein 
adrenergic receptors, structure and function, 229-230 
basic fibroblast growth factor (bFGF) 
structural studies, 387-388 
calcium-mediated hormones, 129-130 
cellular regulation, 375-376 
molecular genetics, nematode development, 399-400 
nerve cell electrical activity, 1-2 
neuronal function, lix 
olfaction and, 331-332 
signal transduction 
transmembrane transduction, 347 
visual systems, 193-194 
visual pigments, 291-292 
G, cyclins, colony-stimulating factor 1 receptor (CSF-IR), 
371-372 
GABA neurotransmitter, synapse-like microvesicles (SLMVs), 
106 
GA-binding protein (GABP), viral gene regulation, 279-280 
GAD, stiff-man syndrome and, 106 
GAL4 protein, macromolecular assembly, 177-178 
gap genes, Drosophila embryogenesis, transcription control, 
112-114 
Garrod, Archibald, xxxix 
GCN4 molecule 
structural predictions, 58 
yeast transcriptional regulator, macromolecular assembly, 
177-178 
Gene cloning, research trends in, xliii 
Gene expression 
adenovirus as control model, 369-370 
animal cells, 293-294 
autoantibody probes, 391-392 
B cell development, 379-380 
calcium channel molecular studies, 529-530 
cell cycle and, 179-180 
cell differentiation and activation, 12, 255-256 
cell lineage in Caenorhabditis elegans, 511-512 
chromosome 7 mapping, 531-532 
developmental control, 173-174 
embryogenesis, 507-508 
eukaryotic, 59-60 
hemoglobin .synthesis, 217-218 
hormonal regulation, 75-76 
keratin, 146-148 
liver regeneration, 411-412 
lymphocyte development, 381-382 
537 
