Index 
Gene expression {continued^ 
mammalian development, 419-420 
mechanisms of, in animal cells, 421-422 
neural development, 208 
pattern regulation in Drosophila and, 65-67 
protein-RNA/DNA interaction, 393-395 
research on, xliii 
retroviral 
cellular transcription, 285-286 
rggulation of, in humans, 95-96 
steroid hormones, biosynthesis, 317-318 
viruses and, 279-280 
visual pigments, 291-292 
Gene isolation, Down syndrome, 237-238 
Gene mapping 
genetic basis of hearing loss and, 1 19-120 
genetic disease and, 141-142 
protein structure and folding, 139-140 
retroviral replication and, 54 
Gene regulation. See Gene expression 
Gene segments, receptor structure and, xlvi-xlvii, li 
Gene structure, xxx, xxxii 
antibody genes, 9-10 
Gene targeting 
antibody genes, 9-10 
embryonic mouse development, 63-64 
Gene therapy. See also Somatic gene therapy 
albinism and, 307-308 
human disease and, 249-250 
inherited disease, 69-70 
T cell receptor functions, 435-436 
Gene transfer, blood cell formation, 446 
Gene trapping, developmental genetics and, 20 
Genetic disease 
cancer as, 247-248 
gene identification and correction, 69-70 
gene mapping techniques, 81-82 
metabolic disorders, gene therapy, 457-458 
molecular studies, 25-26 
research trends in, xlii-xliii 
skin, keratin gene expression, 146-148 
X-linked disorders, 163-164 
Genetic engineering, structural biology and, xli 
Genetics, research programs in, xxxix-xlv 
Genomes 
DNA structure and, xxxix, Ixi 
fragments, Down syndrome, 237-238 
mapping of, xliv 
rearrangement, antibody gene structure, 9-10 
sequencing projects, 77 
structure, xxx 
ges- 1 gene, cell lineage in Caenorhabditis elegans, 
511-512 
Glanzmann's thrombocytopenia, 55-56 
GLI protein, DNA interactions, 310 
Glial cells, function, Iv 
Globin genes, structural determinants, 259-260 
a-Globin gene expression, structural determinants, 259-260 
Glomerular basement membrane, hereditary kidney disease, 
333-334 
Glucagon, gene expression, 175 
Glucocorticoid-remediable aldosteronism (GRA), 244 
Glucocorticoids, steroid hormone gene expression, 317-318 
Glucose transport, molecular genetics of diabetes and, 28 
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), 
transcriptional regulation, 7-8 
Glycogen phosphorylase, structural studies, 388 
Glycolysis/gluconeogenesis, IRE-A DNA-binding protein, 8 
Glycoproteins 
T cell recognition, 443 
viral structure and replication, intracellular transport, 
245-246 
Glycosyltransferases, molecular genetics, 267-268 
Golgi apparatus, structure, xxv 
Gonadotropin-releasing hormone (GnRH), gene mapping, 
142 
Goodpasture syndrome, molecular basis for, 333-334 
GP Ilb-IIIa receptor, tyrosine phosphorylation in platelets, 
55-56 
Graft-versus-host disease (GVHD), coagulation genetics, 162 
Grants for Science Education, xix 
gRNA, RNA editing, 377-378 
groEL protein, protein folding, 189-190 
Growth cone guidance, neuronal recognition and, 169-170 
Growth factors. See also specific growth factors 
cell proliferation and, 447-448 
genomic response, 289-290 
insulin mechanisms and, 43-44 
signal transduction, 517-518 
transcription control, 469-470 
Growth-regulation proteins, blood cell formation, 446 
GTP, transmembrane signal transduction, 347 
GTP-binding protein 
neurotransmitter storage and release mechanisms, 203 
olfaction and, 331-332 
Guanylyl cyclase, second messengers and cell regulation, 
151-152 
Gyrate atrophy (GA), urea-tricarboxylic acid pathways, 
429-430 
HI transcription factor (H1TF2), 179-180 
H-2 molecules, major histocompatibility complex and, 
153-154 
1119 gene, mammalian development, 419-420 
Haemophilus influenzae, host-pathogen interactions, 
493-494 
hairy gene, pattern regulation in Drosophila and, 66 
Hearing loss, genetic basis for, 1 19-120 
Heart function, neuronal excitability, 206 
Heat-shock proteins (HSPs) 
protein 60 (hsp60), 189-190 
stress tolerance and, 261-262 
T cell epitopes, 358 
heavy-chain (a-chain) segments, li 
hedgehog gene, Drosophila morphogenesis, 23-24 
Helix-helix association and stability, 57-58 
Helix-loop-helix 
cell fate control, 14 
DNA interactions, 311 
MyoD gene activation, 433-434 
Helper T cells. See also T cells 
immune response and, xlvi 
Hemagglutinin, influenza virus, 157-158 
Hematopoiesis 
gene expression, 381-382 
normal and leukemic genetics, 485-486 
Hematopoietic stem cells 
blood cell formation, 445 
genetic manipulation, 31-32 
lymphocyte life cycle, 437-438 
molecular genetics of, 305-306 
Hemoglobin 
genetic disease and, xlii-xliii 
molecular genetics of blood cells and, 305-306 
synthesis, genetic control, 217-218 
Hemophilia 
coagulation genetics, 161-162 
X-linked disorders, 163-164 
Heparin, basic fibroblast growth factor (bFGF) and, 387-388 
Hepatitis B virus (HBV) 
replication and pathogenesis, 149-150 
RNA replication and pathogenesis, 240 
surface antigens, 315-316 
Hepatitis delta antigen (HDAg), RNA replication and 
pathogenesis, 240 
538 
