Index 
Hepatitis delta virus (HDV), RNA replication and 
pathogenesis, 240 
Hepatocellular carcinoma, 149-150 
Hepatocellular transplantation, gene therapy and, 249-250 
Hepatocyte nuclear factor 3, eukaryotic gene regulation, 
59-60 
Heterochromatin, position effects, 183-184 
Heterogeneous nuclear ribonucleoproteins (hnRNPs), 
117-118 
High-mobility group (HMG) box, 7-8 
Hippocampus, neuronal excitability, 206 
Histidine, visual pigments, 291-292 
Histocompatibility antigens (H antigens) 
genetics, structure and function, 1 33- 1 34 
molecular structure, 153-154 
T cell receptors, 41 
HLA-B27 glycoprotein, 443 
HNF-1|8 transcription factor, 89-90 
Holoenzyme, DNA replication and, 301-302 
Homeobox genes 
Drosophila melanogaster, 349-350 
embryonic induction mechanisms, 269-270 
motor neuron differentiation, 211-212 
Homeodomain proteins 
Drosophila morphogenesis, 23-24 
DNA interactions, crystal structures, 309-31 1 
DNA-binding specificity, 112-114 
genetic regulatory mechanisms, 89-90 
structural biology and, Ixiii 
Homeotic genes 
Drosophila morphogenesis, 23-24 
genetic control. 223-224 
limb development genetics in Drosophila, 79-80 
Homologous chromosomes, three-dimensional structure, 
360-362 
Homologous recombination, research trends, xliv 
Hormone response elements (HREs), 126 
Hormones 
calcium-mediated, molecular mechanisms, 129-130 
gene expression regulation, 75-76 
molecular biology, 251-252 
Host-pathogen interactions, microbial pathogenesis, 
493-494 
"Housekeeping" genes, complement system, 16 
Hox genes, embryogenesis 
anterior- posterior patterning, 525-526 
induction mechanisms, 269-270 
mouse development, gene targeting, 63-64 
hox- 1 .5 muvmt, 63-64 
hox- 1 .6 mutant, 63-64 
Human foamy virus (HFV), 95-96 
Human growth hormone (hGH), 256 
Human immunodeficiency virus (HIV) 
AIDS and. Hi 
CD4 molecule and, 178 
gene expression, cellular transcription, 285-286 
protein-DNA interaction, 394 
retroviral replication, 53-54 
HIV- 1 and HIV-2, 95-96 
surface glycoproteins, 263-264 
T cell epitopes, 358 
trans-activation, 325-326 
Human leukocyte antigens (HLA), processing mechanisms, 
93-94 
Human myeloid leukemias, lymphocyte growth regulation, 
452-454 
Human T cell leukemia virus (HTLV-I and HTLV-II) 
retroviral gene expression, 95-96 
surface glycoproteins, development and infection, 
263-264 
Humoral immune response 
CD4-bearing T lymphocytes, 5/- 52 
research on, xlvi 
hunchback {hb) gene, Drosophila embryogenesis 
segmentation, 113-114 
transcription control, 113-114, 403 
Huntington disease, gene mapping, 81-82 
Hyperlipidemia, genetic studies of cardiovascular disease, 
243-244 
Hypertension 
blood vessel function, endothelins and, 459-460 
genetic studies, 243-244 
steroid hormone gene expression, 317-318 
Hypoxanthine guanine phosphoribosyltransferase (HPRT), 
69 
IgA deficiency (IgA-D), 84 
Imaginal wing discs, pattern regulation in Drosophila and, 
66-67 
Immediate-early genes (lEGs) 
growth factors, 289-290 
kidney cell growth and differentiation, 407-408 
viral gene regulation, 279-280 
Immune response 
CD4 and CDS molecules, 181-182 
cytokine regulation of effector functions, 513-514 
genetic mechanisms in antibodies, 9-10, 171-172 
genetic research and, 136-138 
leprosy and tuberculosis immunity and pathogenesis, 
47-48 
research on, xlvi-xlvii 
Immune system 
cell development, 83-84 
cell surface recognition, 41 
complement system, 15-16 
research programs on, xlvi 
Immunodeficiency 
gene regulation and, 325-326 
immune system development and, 84 
Immunofluorescence techniques 
gene mapping, 81 
post-transcriptional regulation, 118 
Immunoglobulin 
antigen receptor molecule studies, 351-352 
B cell development, gene expression, 379-380 
developmental control of gene expression and, 173-174 
heavy-chain gene control, 215-216 
K light-chain gene, 159-160 
lymphocyte development, 415-416 
activation and, 109-110 
neoplasia and, 231-232 
Immunology, research programs in, xlvi-liv 
Immunoprecipitation, synaptic transmission, 356 
Immunosuppression, lymphocyte life cycle, 437-438 
Imprinting, cancer as genetic disease and, 248 
In situ hybridization, eukaryotic chromosomes, 360-362 
In vivo gene expression, cellular and retroviral genes, 286 
Inactivation process, ion channels, 5 
Inborn errors of metabolism, gyrate atrophy, 429-430 
Inducible cell adhesion molecule- 1 10 (INCAM-1 10), 39-40 
Infectious disease 
protein crystallography, 521-522 
protein synthesis, 501-502 
RNA replication, 509-510 
Inflammation, vascular endothelium and, 39-40 
Influenza virus 
glycoprotein mechanisms, 443 
structure and replication, 245-246 
Inositol 1,4,5-trisphosphatc (IP3), 257-258 
Insertional mutation 
albinism and, 307-308 
developmental genetics and, 20 
Insulin. See also Insulin-responsive element A (IRE-A) 
mechanisms of action, 43-44 
molecular genetics of diabetes and. 27-28 
production mechanisms for, 389-390 
539 
