Index 
M channel, nerve cell electrical activity, 1-2 
M2 protein, viral structure and replication, 245-246 
M3 molecule, histocompatibility antigen research, 133-134 
Macromolecules 
recognition, protein folding, 225-226 
structural basis of interaction, 277-278 
structural studies, Ixi, 177-178 
three-dimensional structures, 107-108 
Macrophages, immune system, xlvi 
Major histocompatibility complex (MHC) 
antigen processing, 93-94 
B cell development, 299-300 
CD4 and CDS molecules, 182 
class I molecules 
antigen processing, 93-94 
histocompatibility antigen research, 133-134 
class II molecules 
antigen processing, 93-94 
immune tolerance, 136-138 
macromolecular assembly, / 78 
cytotoxic T cells, 37-38 
immune response and, li-lii 
mammalian memory, 423-424 
molecular genetics of, 153-154 
surface glycoproteins, 263-264 
T cells 
activation, 209-210 
development biology, 265-266 
receptor, 435-436 
recognition, 101-102 
Mammalian development 
disease and, 313-314, 315-316 
gene regulation, 419-420 
genetics, 19-20 
X and Y chromosomes, 312-314 
MAP kinases, tyrosine phosphorylation, 56 
MARCKS (myristoylated alanine-rich C-kinase substrates), 
43-44 
Marfan syndrome, gene mapping, 142 
Master regulatory genes, 207-208 
Maternal genes, transcription control, 112-114 
Maternally transmitted antigen (Mta), 133-134 
Maturation-promoting factor (MPF), 271-272 
MCAT protein, retroviral infections, 97-98 
mdr gene family, multidrug resistance, 499-500 
Mechanical adjustment hypothesis, 87-88 
Mechanotransduction, sensory cells, 473 
Medial superior temporal area (MST), 527 
Medical Research Organization (MRO), xix 
Membrane proteins 
cofactor protein, complement system, 16 
energy transduction, 213-214 
Membrane-bound growth factors, 276 
Memory 
cell biological studies, 219-220 
T cells and, 423-424 
in vitro generation, 102 
Mendelian genetics, genetic structure and, xxxix 
Mental retardation, X-linked disease, 295-296 
Messenger RNA (mRNA) 
decoding code, 155-156 
gene expression and, 117-118 
a-globin gene expression, 259-260 
splicing studies, 337-338 
transcription and, xxx, xxxiii 
Metamorphosis, molecular regulation, 417-418 
Metastasis 
tissue-type plasminogen activator (t-PA), 157-158 
vascular endothelium and, 39-40 
Methyl-malonyl CoA mutase (MCM), gene therapy with, 
249-250 
Microfilaments, cytoskeleton structure, xxxv 
/Sj-Microglobulin, polymorphism, 134 
Microtubules 
cytoskeleton structure, xxxv 
linkage analysis and, 81 
Missense mutations, familial hypertrophic cardiomyopathy 
(FHC), 363-364 
Mitochondria 
histocompatibility antigen research, 134 
matrix, protein folding, 189-190 
structure, xxxv 
Try panosome genome, 378 
Mitosis, cell cycle control, 21-22 
Molecular biology, research trends in, xxx 
Molecular engineering, cell structure and neurobiology, 
426-428 
Molecular fractionation, synaptic transmission, 355-356 
Molecular recognition 
eukaryotic gene regulation, 59-60 
structural biology and, Ixiii 
Moloney murine leukemia virus (MoMuLV) 
developmental genetics and, 20 
hematopoietic stem cell regulation, 31-32 
retroviral infections, 97-98 
Monoclonal antibodies, scorpion toxin receptor genes, 
519-520 
Monocytes, HIV gene expression, 285-286 
Morphogen gradients, Drosophila body patterns, 403-404 
Morphogenesis, genetic control, 223-224 
Motor neurons, differentiation, 211-212 
Mouse development 
antibody genes, 9-10 
gene targeting and, 63-64 
genetics, 19-20 
Multiplex sequencing, genomes, 77 
Muscle development and function 
molecular analysis, 287-288 
MyoD gene family, 433-434 
Muscular dysgenesis (rndg) gene, 409 
Muscular dystrophies. See also specific muscular dystrophies 
gene mapping, 141 
molecular genetics, 233-234 
neuronal function, Ix 
Mutations 
detection, gene mapping, 141-142 
gene cloning and, xliii 
ion channels, molecular mechanisms, 5 
Myasthenia gravis, neuronal function, Iv 
Mycobacteria 
genetic control of disease, 200-202 
leprosy and tuberculosis immunity and pathogenesis, 
4 7-48 
Myeloid cells, growth control, 371-372 
Myoblasts, as recombinant protein delivery system, 256 
Myocyte-specific enhancer-binding factor 2 (MEF2), 
287-288 
MyoD gene family 
muscle cell lineage, 433-434 
transcriptional regulation, 287-288 
Myosin heavy chain (MHC) 
familial hypertrophic cardiomyopathy (FHC), 363-364 
transcriptional regulation, 287-288 
nana gene, Drosophila development and, 253-254 
Nectins, cell adhesion and, 195-196 
Nematode development 
genetic control, 187-188 
molecular genetics, 399-400 
Nerve cell structure, liv 
Nerve grov^^h factor (NGF) 
cell fate control, 11-12 
transcription control, 469-470 
tyrosine phosphorylation, 56 
Nerve impulses, structure and function, Iv 
541 
