Index 
Nervous system 
biological clock system, 465-466 
cell fate in, 13-14 
Neural crest cells, cell fate control, 11-12 
Neural networks, sensory representations, visual system, 
367-368 
Neuroendocrine system, molecular mechanisms, 339-340 
Neurogenesis 
cell pattern control, 211-212 
pattern regulation in Drosophila and proneural genes, 
66-67 
visual systems, 341-342, 396-398 
Neuroimmunology, molecular studies, 319-320 
Neuromodulation, caffeine consumption and, 401-402 
neuromusculin (nrm) gene, 29-30 
Neuron doctrine, liv 
Neuronal development 
calcium channel molecular studies, 529-530 
cell fate control, 11-12 
extracellular matrix, 335-336 
Neuronal excitability, voltage-sensitive potassium channels, 
205-206 
Neuronal recognition 
growth cone guidance and, 169-170 
visual systems, 396-398 
Neuronal survival, neuron development, 335-336 
Neurons 
differentiation, olfaction and, 332 
molecular engineering, 426-428 
secretory pathways, 405-406 
structure and function, liv 
synaptic vesicle traffic in, 105-106 
Neuropeptides, synaptic transmission, 355-356 
Neurophysiology, visual systems, 283-284 
Neuroscience, research programs in, liv-lx 
Neurotransmitters 
function, Iv 
neuronal secretory pathways, 405-406 
receptors, synaptic transmission, 192 
storage and release mechanisms, 203 
synaptic vesicle proteins, 105-106 
transcription control, 469-470 
Neurotrophic factors, cell fate control, 11-12 
NF-kB protein, signal transduction in B cells, 159-160 
Nitric oxide, retroviral infections, 97-98 
Non-self lymphocytes, immune response, xlvi 
nos gene, translation repression of bb, 403-404 
Notch gene 
biological clock system, 465-466 
cell fate control, 13-14 
viral gene regulation, 280 
Nuclear envelope, eukaryotic chromosomes, 360-362 
Nuclear factor 
of activated T cells (NFAT), 90 
gene expression regulation, 75-76 
Nuclear lamina, protein translocons and, 45-46 
Nuclear magnetic resonance (NMR) 
accuracy of crystal and solution, 57 
chromosome structure, 3-4 
extracellular matrix structure, 49 
protein structure and folding, 139-140 
structural biology and, Ixiii 
Nuclear pore complexes (NPC) 
protein translocons and, 45-46 
structure and function, 99-100 
Nuclear structures, xxx 
post-transcriptional regulation, 117-118 
Nucleoporins, nuclear pore complex (NPC), 99-100 
NUPl gene, nuclear pore complex (NPC), 99-100 
Obesity 
IRE-A DNA-binding protein, 8 
molecular biology and, 143-144 
Oct-2 protein, B cell development, 379-380 
Olfaction 
molecular approaches to, 331-332 
molecular biology, 17-18 
second-messenger ion channel regulation, 373-374 
Oligonucleotide, calcium channel molecular studies, 
529-530 
Oligosaccharide 
epitopes, protein structure and function, 329-330 
glycosyltransferase molecular genetics and, 268 
Onchocerciasis, immune evasion and, 116 
Oncogenes. See also specific genes, e.g., src gene 
adenovirus transcriptional regulation, 293-294 
cell structure and, xxxviii 
colony-stimulating factor 1 receptor (CSF-IR), 371-372 
early embryogenesis and, 297-298 
gene regulation mechanisms and, 421-422 
lymphocyte development, molecular genetics, 231-232 
mammalian development studies and, 315-316 
Optical/electron microscopy, eukaryotic chromosomes, 
360-362 
Organelles, structure, xxxv 
Organogenesis, transcription control, 114 
Ornithine transcarbamylase (OTC) deficiency, 70 
Ornithine-5-aminotransferase (OAT), 429-430 
Outer membrane proteins (OMP), 487-488 
Outer surface protein (OspA & B), 138 
Oxidative stress, redox proteins and, 236 
Ox}'R protein, oxidative stress mechanism, 236 
Oxytricba nova. DNA molecular structure, 72 
p53 gene 
hematopoiesis, 486 
transcription regulation mechanisms, 496 
paired ^ene, Drosopbila embryogenesis, 114 
Pair-rule segmentation genes, 65-67 
Pancreatic /3-cell, diabetes and, 27-28 
Papillomaviruses, human (HPV), molecular biology of, 
241-242 
Paramyxovirus, structure and replication, 245-246 
Parasites, immune evasion by, 115-116 
patcbed gene, Drosopbila morphogenesis, 23-24 
Pathway recognition, growth cone guidance and, 169-170 
Pattern formation 
Drosopbila body patterns, morphogen gradients, 403-404 
limb development genetics in Drosopbila, 79-80 
fax genes, embryonic induction mechanisms, 269-270 
PC 12 cells, tyrosine phosphorylation, 56 
Peptides 
neurotoxins, ion channels, 281-282 
structure, protein folding, 225-226 
Peptidyl-tRNA hydrolase (Pth), protein synthesis, 501-502 
per gene 
biological clock system, 465-466 
mRNA processing and behavior, 337-338 
Perception, neurophysiology, 283-284 
Peripheral nervous system 
Drosopbila development, 29-30 
growth cone guidance and, 169-170 
olfaction and, 17-18 
Peyer's patches, gene regulation of, 437-438 
P-glycoprotein (P-gp), multidrug resistance, 499-500 
pH regulation, leukocyte homeostasis, 498 
Phage X, protein synthesis, 501-502 
Phagocytes, Legionella pnuemopbila growth in, 198 
Phase determination, structural biology and, Ixi 
Phenotype, neuronal function, lix 
Phenylalanine hydroxylase (PAH), somatic gene therapy, 
457-458 
Phenylketonuria (PKU), somatic gene therapy, 457-458 
Phosphatidic acid (PA), calcium-mediated hormones, 130 
Phosphatidylcholine (PC), calcium-mediated hormones, 130 
542 
