Index 
Phosphatidylinositol (PI) 
metabolism, 327-3-28 
phospholipids and cell regulation, 165-166 
Phosphatidylinositol 3-kinase (PI3-kinase), 122 
Phosphatidylinositol 4,5-bisphosphate (PIP2), 129-130 
Phosphatidylinositol monophosphate phosphatase, 327-328 
Phospholipase A^, cellular regulation, 375-376 
Phospholipase C, calcium-mediated hormones, 129-130 
Phospholipids, cell regulation, 165-166 
Phosphorylation. See also Tyrosine phosphorylation 
epidermal growth factor (EGF), 103-104 
RNA polymerase II structure and function, 85-86 
signal transduction, 517-518 
Phosphotyrosine protein phosphatase, synaptic transmission, 
192 
Photosynthesis, molecular genetics, 503-505 
Phototransduction, visual systems, 193-194 
piebald gene, mammalian development, 419-420 
Pilin, protein crystallography, 521-522 
Pit-1 gene, neuroendocrine system, 339-340 
Plasma cells, immune response and, xlvi 
Plasma membranes 
ankyrins in, 33-34 
protein translocons and, 45-46 
Plasminogen activator inhibitor- 1 (PAI-1), 161-162 
Platelet-derived growth factor (PDGF) 
Drosophila melanogaster signal transduction, 323 
genomic response, 289-290 
Platelets, tyrosine phosphorylation, 55-56 
Pole plasm, Drosophila development and, 253-254 
Poliovirus, genetics, 227-228 
Polyadenylation, molecular mechanisms, 293-294 
Polymerase chain reaction (PGR) 
gene mapping, xliv 
genetic basis of hearing loss and, 119-120 
hematopoietic stem cell regulation, 32 
major histocompatibility complex, 153-154 
viral genetics, 227-228 
Polypeptide growth factors, action mechanisms in, 327-328 
Polypeptide hormones, gene regulation, 175-176 
Ponder-Richards rotamers, chromosome structure, 4 
Population dynamics, PKU gene distribution, 457 
Positional cloning 
gene mapping and, 81-82 
obesity and diabetes, 143-144 
Potassium channels 
cystic fibrosis transmembrane conductance regulator 
(CFTR), 440 
functional mechanisms, 281-282 
insulin production, 390 
molecular mechanisms, 5-6 
nerve cell electrical activity, 1-2 
neuronal excitability, 205-206 
scorpion toxin receptor genes, 519-520 
POU domain, neuroendocrine system, 339-340 
Prader-Willi syndrome, 141 
Pre-B cell, gene expression and, 175 
Pre-messenger RNA, splicing mechanisms, 337-338 
Prenatal diagnosis, genetic disease, 457-458 
Prepattern genes, neural development, 207-208 
proboscipedia gene, morphogenesis, 223-224 
Prohormone-converting enzymes, 389-390 
Prokaryotic repressors, protein-DNA interactions, 309-3 1 1 
Prolactin secretion, functional heterogeneity, 489-490 
Promoters 
peripheral nervous system development, 29-30 
trapping, developmental genetics, 383-384 
Proncural genes, pattern regulation in Drosophila and, 
66-67 
Protein kinase A (PKA), gene expression and cell cycle, 
179-180 
Protein kinase C, sensory transduction, 473 
Protein kinases 
carboxyl-terminal domain (GTD), 85-86 
cell cycle control, 21-22 
cell division and, xxxvi 
epidermal growth factor (EGF) desensitization, 328 
insulin mechanisms and, 43-44 
protein sorting and, 1 22 
signal transduction, dual-specificity, 518 
synaptic transmission, 192 
tyrosine phosphorylation in platelets, 55-56 
Protein-DNA interaction. See also DNA-binding proteins 
cAMP-dependent, gene expression, 175-176 
Drosophila embryogenesis, 114 
macromolecules, 278 
RNA molecular structure, 72 
Protein-protein interactions, signal transduction, 517-518 
Proteins 
design, protein folding, 225-226 
folding 
chromosome structure, 4 
genetic research and, 139-140 
histocompatibility antigen research, 133-134 
in vivo research, 189-190 
macromolecular interaction, 276-278 
intracellular transport, 353-354 
ion channels, functional mechanisms, 281-282 
macromolecular interaction, 276-278 
phosphorylation 
cell cycle control and, 27 1-272 
synaptic transmission, 191-192 
regulatory proteins, 387-388 
sorting, molecular genetics, 121-122 
structure/function studies, xxx, xxxiv, Ixi, 329-330 
synthesis, viral infection, 501-502 
as transcriptional factor, xxxv 
translocons, nuclear organelles and, 45-46 
Protein-tyrosine kinase (PTK) 
lymphocyte signaling, molecular basis for, 321-322 
T cell receptor functions, 435-436 
Protein-tyrosine phosphatases, lymphocyte activation, 
413-414 
Proton pumps, leukocyte homeostasis, 498 
Proto-oncogenes, embryonic mouse development, 63-64 
P-selectin gene, genetic disease and, 26 
Pseudoknots, mRNA decoding, 1 56 
Pseudomonas aeruginosa, protein crystallography, 
521-522 
pumilio gene, 253-254 
Q-beta replicase, RNA replication, 509-510 
R values, NMR accuracy, 57 
R7 cells, retinal cell-cell interactions, 471-472 
RAG genes 
antibody genes, 9-10 
lymphocyte differentiation, 110 
RAG-1 protein, 351-352 
RAG-2 protein, 351-352 
ras protein 
tyrosine phosphorylation, 56 
visual system development, 342 
reck protein, protein-DNA interaction, 394-395 
Receptor-ligand interaction 
chromosome structural studies, 4 
macromolecules, 278 
Receptors. See also specific receptors, e.g., T cell receptor 
adrenergic receptors, biosynthesis, 229-230 
antigen-specific, 351-352 
cell structure and, xxxvi 
gene segments and, xlvi, li 
macromolecular assembly, 178 
olfaction and, 17-18 
periplasmic, active transport and chemotaxis, 330 
