Index 
Receptors {continued) 
retroviral infections, 97-98 
transforming growth factor (TGF), 103-104 
Recombination 
antigen receptor molecule studies, 351-352 
DNA technology, xxxix, xliii 
Down syndrome and, 237-238 
genetic disease research, 25-26 
protein-DNA interaction, 394 
RNA viruses, 239-240 
transposition mechanism, 91-92 
Recoverin 
signal transduction, visual systems, 193-194 
urea/tricarboxylic acid cycles, 430 
Redox proteins, transcriptional response, 236 
Regenerating liver inhibitory factor {RL/IF-1), 411-412 
Regulation, molecular mechanisms, 339-340 
Regulatory molecules 
cell fate control, 12 
structural studies, 387-388 
Replication 
cell cycle control, 21-22 
in DNA, 301-302 
protein-DNA interaction, 393-395 
viral pathogenesis and, 149-150 
Resolvase, protein-DNA interaction, 394-395 
Restriction fragment length polymorphism (RFLP) 
cerebellum development, 180 
gene mapping, xliv 
neurological disorders, Ix 
obesity and diabetes, 143-144 
tuberculosis infections and, 200-202 
Wilms' tumor genes, 131 
Retinal degeneration, molecular genetics, 295-296 
Retinal rods and cones, phototransduction mechanism, 
461-462 
Retinitis pigmentosa, gene expression in visual pigments, 
292 
Retinoblastoma, adenovirus transcriptional regulation, 
293-294 
Retinoic acid (RA), embryogenesis, 525-526 
Retinoic acid receptors (RARs), response pathway, 125-127 
Retinoid X receptors (RXRs), response pathway, 125-127 
Retrovirus 
correction of methyl-malonyl CoA mutase (MCM), 
249-250 
developmental genetics and, 20 
gene expression, 95-96 
cellular transcription, 285-286 
hematopoietic stem cell regulation, 31-32 
infection mechanisms, 97-98 
replication and, 53-54 
Rev protein, retroviral gene expression, 95-96 
Rev response elements (RRE), 96 
"Reverse genetics." See also Positional cloning 
genetic basis of hearing loss and, 119-120 
Rheumatoid arthritis (RA) 
immune tolerance, 136-138 
T cell function in, 273-274 
Rhodopsin, transmembrane signal transduction, 347 
Rhombomeres, developmental genetics and, 19-20 
Ribosomal jumping, mRNA decoding, 155-156 
Ribosomal pausing, tRNA molecules, 455 
Ribosome frameshifting, translational regulation, 455 
Ribozymes, RNA replication, 509-510 
Ring complexes, protein folding, 190 
RMA-S mutant cells, histocompatibility antigen research, 134 
RNA 
catalysis, 71-72 
chromosome end structure, 71-72 
editing, Trypanosome genomes, 377-378 
recombination, viral genetics, 227-228 
replication in infectious disease, 509-510 
synthesis, RNA viruses, 239-240 
viruses 
genetics, 227-228 
replication and pathogenesis, 239-240 
RNA polymerase, structural biology and, Ixi 
RNA polymerase II 
post-transcriptional regulation, 118 
structure and function, 85-86 
transcription regulation mechanisms, 495-496 
RNA-binding domain (RBD), post-transcriptional regulation, 
117-118 
RNA-protein interaction 
post-transcriptional regulation, 117-118 
structural biology and, Ixi, 393-395 
Rotavirus diarrhea, control epidemiology, 483-484 
Rough endoplasmic reticulum (RER), xxxv 
RPS4X, 314 
RPS4Y, 314 
RuBisCO 
NMR accuracy, 57 
photosynthesis genetics, 503-505 
Saccharomyces cerevisiae 
DNA cloning, 303-304 
heat-shock proteins (HSPs), 261-262 
lysosomal hydrolase sorting, 121 
nuclear pore complex (NPC), 99-100 
research with, xliv 
RNA polymerase II structure and function, 85-86 
secretory process, 353-354 
Salmonella typhi. See Typhoid fever 
Sarcomere, muscle development and function, 287-288 
Scleroderma, autoantibody probes, 392 
Second messenger systems 
cell regulation, 151-152 
cell structure and, xxxvi 
ion channel regulation, 373-374 
neuronal function, lix 
caffeine consumption, 401-402 
synaptic transmission, 192 
Secretory process 
intracellular transport, 353-354 
neuronal pathways, 405-406 
vesicle transport, 354 
Segment polarity genes 
cell-cell interactions, 298 
Drosophila morphogenesis, 23-24 
Segmentation 
developmental genetics and, 19-20 
Drosophila embryogenesis, 113-114 
Drosophila morphogenesis, 23-24 
Selectins 
cell adhesion and, 196 
in inflammation and metastasis, 39-40 
Self antigens, immune response and, li 
Self lymphocytes, immune response, xlvi 
Self-reactive T cells, 136-138 
Self-tolerance 
biology of T cell development, 265-266 
mechanisms, 171-172 
Selfish (junk) DNA, xxx 
Sensory perception, olfaction and, 17-18 
Sensory-motor interface, representation-transformation, 
523-524 
Sequencing 
gene cloning and, xliii 
recent technology trends, 77 
Serotonin, molecular engineering, 426-428 
seven-in-absentia (sina) gene, 342 
sevenless gene, visual system development, 341-342 
Severe combined immunodeficiency (SCID) 
antibody gene structure, 9-10 
544 
