Index 
T cells. See also Cytotoxic T cells; Helper T cells 
activation and differentiation, 89-90, 209-210 
cell surface molecule regulation, 436 
afi, mammalian memory, 423-424 
biology of development, 265-266 
CD4-bearing, 51-52 
development, 9-10 
epitopes. Salmonella typhi attenuated strains as, 358 
76, mammalian memory, 423-424 
gene.sequences and, li 
HIV gene expression, 285-286 
immune system development and, xlvi, 83-84 
memory and. 423-424 
molecular regulation, 415-416 
recognition and differentiation, 101-102 
role of, in health and sickness, 273-214 
subsets, cytokine regulation of effector functions, 
513-514 
surface glycoproteins, development and infection, 
263-264 
V/3 superantigen, function in health and disease, 273-274 
Target recognition 
growth cone guidance and, 170 
neural development, 207-208 
Tat protein, retroviral gene expression, 95-96 
TATA box, lymphocyte development, 382 
TATA-binding protein (TBP), transcription regulation, 422 
TdT (terminal deoxynucleotidyltransferase) gene, 381-382 
Telomeres 
hereditary kidney disease, 333-334 
RNA molecules, 7/- 72 
Testis-determining factor, IRE-A DNA-binding protein, 7-8 
Tetrahymena thermophila enzyme, 71 
TflllA, macromolecular assembly, 177-178 
Thalassemia 
o:-globin gene expression, 259-260 
prenatal diagnosis, hemoglobin synthesis, 217-218 
(3-Thalassemia (Cooley's anemia), 305-306 
Three-dimensional structure, eukaryotic chromosomes, 
360-362 
"3-4-5" rule, hormone receptor genetics, 126 
Thrombin, blood clotting regulation, 344-346 
Thrombolysis, tissue-type plasminogen activator (t-PA), 
157-158 
Thrombomodulin, blood clotting regulation, 344-346 
Thrombosis, prevention of clotting, 123-124 
Thymidine kinase (TK), viral gene regulation, 279-280 
Thyroid hormone, receptor genetics, 125-127 
Thyroid hormone receptors (TRs), 75-76 
Thyroid hormone-responsive elements (TREs), 75-76 
Thyroid-stimulating hormone (TSH) 
gene expression regulation, 75-76 
post-transcriptional action, 76 
Time-resolved imaging, structural biology and, Ixiii 
Tissue factor, blood clotting regulation, 344-346 
Tissue specificity, epidermal growth factor (EGF), 104 
Tissue-type plasminogen activator (t-PA) 
coagulation genetics, 161-162 
human disease and, 157 
Tn7 transposon, 91-92 
toll gene, signal transduction in B cells, 159-160 
Topoisomerase II, eukaryotic chromosomes, 361 
torso gene, embryogenesis transcription control, 112-114 
Trans-activating proteins, gene regulation mechanisms and, 
421-422 
Transacylase, phospholipids and cell regulation, 165-166 
Transcription 
cell structure and, xxx 
cellular 
gene expression, 285-286 
cellular regulation, 375-376 
developmentally regulated genes, 422 
Drosophila embryogenesis, 112-114 
genetic disease and, xlii-xliv 
insulin mechanisms and, 43-44 
metamorphosis, 417-418 
molecular mechanisms, 339-340 
muscle development and function, 287-288 
MyoD gene activation, 433-434 
promoter-specific regulation, 421-422 
regulation mechanisms, 495-496 
RNA polymerase 11 structure and function, 85-86 
transmembrane signals, 469-470 
Transcription factor IID (TFIID), 59-60 
Transcription factors. See also Proteins 
gene expression, adenovirus as control model, 369-370 
genomic response and, 289-290 
kidney cell growth and differentiation, 407-408 
molecular genetics of blood cells and, 305-306 
polypeptide hormones, / 75- / 76 
viral gene regulation, 279-280 
Transcriptional regulatory complexes, 177-178 
Transducin 
signal transduction, visual systems, 193-194 
transmembrane signal transduction, 347 
Transfer RNA (tRNAs) 
ribosomal pausing, 455 
structural biology and, Ixi 
Transforming genes, papillomavirus molecular biology, 242 
Transforming growth factor-a (TGF-a:) 
cell regulation, 275-276 
signal transduction of receptor, 103-104 
Transforming growth factor-/? (TGF-/3) 
cell regulation, 275-276 
limb development genetics in Drosophila, 79-80 
Transgenic mice 
albinism and, 307-308 
B cell development, 299-300 
developmental genetics, 383-384 
extracellular matrix structure, 49 
genetic basis of cancer and, 247-248 
a-globin gene expression, 260 
immunological self-tolerance and autoimmunity, 1 71- 1 72 
mammalian development studies and, 313-314, 315-316 
phagocytic cells, molecular genetics of blood cells and, 
306 
research with, xliv 
shock pathogenesis, tumor necrosis factor (TNF) and, 
35-36 
Transgenic plants, photosynthesis genetics, 503-505 
Transient gene expression, gene therapy and, 250 
Trans-inactivation, position effects, 183-184 
Translation 
cell structure and, xxx 
insulin mechanisms and, 43-44 
mRNA protein synthesis, 455 
Translocation 
intracellular protein transpon, 353-354 
lymphocyte development, molecular genetics, 231-232 
Transmembrane signaling, cellular regulation, 375-376 
Transmitters, cell structure and. xxxvi-xxxvii 
Transplantation 
antigens, immunodeficiency and, 325-326 
coagulation genetics, 162 
complement system, 16 
Transport functions, egg structure-function studies, 386 
Transporters, cell structure and, xxxvi 
Transposition, mechanism of, 91-92 
Trembler gene, Charcot-Marie-Tooth disease and, 141 
Tricarboxylic acid cycle, metabolic pathways, 429-430 
Trophozoites, Entamoeba histolytica detection and 
cloning, 516 
cv-Tropomyosin (TM) gene, protein diversity and, 288 
Trypanosoma brucei rhodesiense, 140 
Trypanosomes, mitochondrial genome, 377-378 
Trypanosomiasis, immune evasion and, 115-116 
546 
