Index 
Tuberculosis 
epidemiological analysis, 200-202 
immunity and pathogenesis, 47-48 
Tumor necrosis factor (TNF) 
inflammatory cytokines, 73- 74 
regulatory proteins, 387-388 
shock pathogenesis, 35-36 
Tumor necrosis factor-a (TNF-a), structural studies, 
387-388 
Tumor necrosis factor-/3 (TNF-/J), structural studies, 
387-388 
Tumors, cholecystokinin regulation and, 144 
Tumor-suppressor genes 
current research on, 131-132 
p53 protein, tissue-type plasminogen activator (t-PA), 
157-158 
Turner syndrome, X and Y chromosomes, 314 
Type 1 collagen, extracellular matrix, 49 
Typhoid fever 
microbial pathogenesis, 493-494 
molecular biology, 487-488 
vaccines with attenuated typhoid strains, 358 
Tyrosinase, albinism and, 307-308 
Tyrosine hydroxylase (TH), transcription control, 469-470 
Tyrosine kinases 
cell cycle control, 21-22 
host-pathogen interactions, 493-494 
signal transduction, 518 
Tyrosine phosphorylation, cell regulation, 55-56 
Ultrabithorax gene , Drosophila morphogenesis, 24 
Upstream stimulatory factor (USF), 59-60 
Urea cycle, metabolic pathways, 429-430 
Vaccines 
immune response and, liv 
leprosy and tuberculosis immunity and pathogenesis, 
47-48 
rotavirus diarrhea, 483-484 
Salmonella typhi attenuated strains as, 358 
T cell repertoire, superantigens, 221-222 
Variability, Entamoeba histolytica, 515-516 
Variable domains, protein chains, xlvi 
Variable surface glycoprotein (VSG), 115-116 
Vascular disease, prevention of clotting, 123-124 
Vascular smooth muscle cells, blood vessel function, 
459-460 
Vasospasm, blood vessel function, 459-460 
VDJ recombination, antigen receptor molecule studies, 
9-10, 351-352 
Vertebrates 
embryonic induction mechanisms, 269-270 
nervous system, cell fate control, 11-12 
Vesicle transport, secretory pathways, 354 
vestigial gene . pattern regulation and, 66-67 
Viral packaging, RNA viral genetics, 227-228 
Viral protein 16 (VPl6), 279-280 
Viral replication and pathogenesis, molecular basis of, 
149-150 
Viral snRNPs, autoantibody probes, 392 
Viruses. See also specific viruses, e.g.. Papillomaviruses 
genetics, RNA, 227-228 
macromolecular assembly, 178 
mammalian gene regulation and, 279-280 
Visual systems 
chromosome 7 mapping, 531-532 
Drosophila 
development in, 341-342 
pattern formation and neuronal cell recognition, 
396-398 
neural foundations, 283-284 
phototransduction of retinal rods and cones, 461-462 
sensory representations, 367-368 
signal transduction, 193-194, 473 
spatial information, 527 
visual pigment molecular biology, 291-292 
Vitamin D receptor (VDR), hormone receptor genetics, 126 
Voltage-clamp technique, nerve cell electrical activity, 1-2 
Voltage-dependent sodium channels, 33-34 
Voltage-gated calcium channels, 61-62 
Voltage-gated ion channels, 5-6 
von Recklinghausen neurofibromatosis (NFl), 81 
von Willebrand disease 
blood clotting regulation, 344-346 
molecular genetics, 161-162 
von Willebrand factor 
blood clotting regulation, 344-346 
molecular genetics, 161-162 
VPl protein, macromolecular assembly, 178 
VP4 protein, rotavirus diarrhea, 483-484 
VP7 protein, rotavirus diarrhea, 483-484 
Vpsl5 protein (Vpsl5p), 122 
Vps34 protein (Vps34p), 122 
White blood cells, molecular genetics of, 305-306 
white-spotting (W) gene, normal and leukemic 
hematopoiesis, 485-486 
Wilms' tumor (WT), 131-132 
wingless gene 
Drosophila morphogenesis, 23-24 
limb development genetics in Drosophila, 79-80 
oncogenesis, 297-298 
Wnt-\ gene family, early embryogenesis, 297-298 
Wound healing, cell adhesion and, 195-196 
X chromosome 
disorders, gene identification and correction, 69- 70 
mammalian development, 312-314 
molecular genetics, 295-296 
structure, xxx, xxxiii 
X-linked disorders, 163-164, 431-432 
X-linked disorders, 163-164, 431-432 
Xq28 chromosome region, X-linked disorders, 163-164 
X-ray crystallography 
cell-surface recognition, 41 
structural biology and, Ixi, 57-58 
Y chromosomes, mammalian development, 312-314 
Yeast artificial chromosomes (YACs) 
chromosome 7 mapping, 531-532 
cloning techniques, 82 
DNA, large-scale analysis, 303-304 
gene expression and cell cycle, cerebellum development, 
180 
mitochondria, protein translocons and, 45-46 
molecular genetics, neuromuscular disease, 233-234 
obesity and diabetes, 144 
research with, xliv 
RNA viral genetics, 227-228 
tumor-suppressor genes, 131 
urea/tricarboxylic acid cycles, 429-430 
Yersinia pseudotuberculosis. 197-198 
YY-1 transcription factor, gene expression, 369-370 
Zellweger syndrome, urea/tricarboxylic acid cycles, 430 
ZFX genes, sex determination, 312-314 
ZFY genes, sex determination, 312-314 
zif 268 gene, DNA interactions, 309-31 1 
Zinc finger proteins 
DNA interactions, crystal structures, 309-31 1 
kidney cell growth and difl'erentiation, 408 
structural biology and, Ixiii 
Zygotic genes, Drosophila embryogenesis, 112-114 
547 
