tandem, 33-amino acid repeats. Each repeat con- 
tains both highly conserved and variable areas of 
sequence. Ankyrin repeats are of particular interest, 
since very similar 33-amino acid repeats are found 
in proteins involved in developmental regulation in 
Drosophila and cell cycle regulation in yeast. Evi- 
dence was recently obtained that one or more of 
the repeats are likely to be involved in binding to 
the anion exchanger. It v^^ill be important to deter- 
mine if the binding site involves variable or con- 
PUBLICATIONS 
served regions within repeats, how many repeats 
are involved in binding, and whether repeats are 
utilized by other proteins that associate with an- 
kyrin, such as the Na^,K^ ATPase and voltage-sensi- 
tive sodium channel. These studies will provide 
clues to the potential diversity of binding sites of 
ankyrin and evolution of ankyrin-binding proteins. 
Dr. Bennett is also Professor of Biochemistry at 
Duke University Medical Center. 
Books and Chapters of Books 
Bennett, Y , Steiner, J. , and Davis, J. 1989. Strategies in regulation of protein associations of the spectrin- 
based membrane skeleton. In Cytoskeletal and Extracellular Proteins: Structure, Interactions and As- 
sembly (Aebi, U., and Engel, J., Eds.). Heidelberg: Springer-Verlag, pp 319-327. 
Gardner, K., and Bennett, V 1989. Recently identified erythrocyte membrane-skeletal proteins and interac- 
tions: implications for structure and function. \n Red Blood Cell Membranes: Structure, Function, Clinical 
Implications (Agre, P., and Parker, J. C, Eds.). New York: Dekker, pp 1-29. 
Articles 
Bennett, V 1989. The spectrin-actin junction of erythrocyte membrane skeletons. Biochim Biophys Acta 
988:107-121. 
Bennett, V, Steiner, J., and Davis, J. 1988. Diversity in protein associations of the spectrin-based membrane 
skeleton of nonerythroid cells. Protoplasma 145:89-94. 
Davis, J., Davis, L., and Bennett, V 1989. Diversity in membrane binding sites of ankyrins. Brain ankyrin, 
erythrocyte ankyrin, and processed erythrocyte ankyrin associate with distinct sites in kidney microsomes. 
JBiolChem 264:6417-6426. 
Davis, L., Lux, S.E., and Bennett, V 1989- Mapping the ankyrin-binding site of the human erythrocyte anion 
exchanger./ 5?o/ Chem 264:9665-9672. 
Kaiser, H.W, O'Keefe, E.J., and Bennett, V 1989. Adducin:Ca"'" """-dependent association with sites of cell-cell 
contact./ Cell Biol 109:557-569^ 
O'Keefe, E.J., Erickson, H.P, and Bennett, V 1989- Desmoplakin I and desmoplakin II. Purification and char- 
acterization./ fizo/ Chem 264:8310-8318. 
Steiner, J. P., and Bennett, V 1988. Ankyrin-independent membrane protein-binding sites for brain and eryth- 
rocyte spectrin./ B?o/ Chem 263:14417-14425. 
Steiner, J. P, Walke, H.T, Jr., and Bennett, Y 1989- Calcium/calmodulin inhibits direct binding of spectrin to 
synaptosomal membranes./ B?o/ Chem 264:2783-2791. 
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