a^Pj, a^Pj). These integrin receptors are all recep- 
tors for fibronectin, albeit for different regions, in- 
cluding, in the case of a^Pj, one of the alternatively 
spliced segments. 
In parallel with these studies on integrins, talin, 
one of the cytoskeletal proteins thought to interact 
with integrins, has been cloned and sequenced. 
This has allowed definition of its overall structure 
and the homology of one domain with other 
membrane-associated cytoskeletal proteins. These 
PUBLICATIONS 
clones are now being used to determine the bind- 
ing sites for potential interacting proteins, includ- 
ing integrins, vinculin, and calpain. The aim is to 
elucidate the molecular structure of the "focal con- 
tact" where extracellular matrix is connected to the 
cytoskeleton via integrins. This is an important 
point of regulation of cell behavior. 
Dr. Hynes is also Professor of Biology at the Mas- 
sachusetts Institute of Technology. 
Books and Chapters of Books 
Hynes, R.O. 1989 ■ Fibronectins . New York: Springer-Verlag. 
Hynes, R.O. , DeSimone, D.W, Lawler, J.J., Marcantonio, E.E., Norton, P.A., Odermatt, E., Patel, R.S. , Paul, J. I., 
Schwarzbauer, J.E., Stepp, M.A., and Tamkun, J.W 1989. Nectins and integrins: versatility in cell adhesion. 
InMorphoregulatory Molecules. New York: Wiley, pp 173-199. 
Articles 
ffrench-Constant, C, and Hynes, R.O. 1988. Patterns of fibronectin gene expression and splicing during cell 
migration in chicken embryos. Development 104:369-382. 
fifrench-Constant, C, and Hynes, R.O. 1989. Alternative splicing of fibronectin is temporally and spatially reg- 
ulated in the chicken embryo. Development 106:375-388. 
ffrench-Constant, C, Van De Water, L., Dvorak, H.F., and Hynes, R.O. 1989. Reappearance of an embryonic 
pattern of fibronectin splicing during wound healing in the adult rat. J Cell Biol 109:903-914. 
Hynes, R.O., Marcantonio, E.E., Stepp, M.A., Urry, L.A., and Yee, G.H. 1989. Integrin heterodimer and recep- 
tor complexity in avian and mammalian cells. / Cell Biol 109:409-420. 
Lawler, J., Weinstein, R., and Hynes, R.O. 1988. Cell attachment to thrombospondin: the role of Arg-Gly-Asp, 
calcium, and integrin receptors. J Cell Biol 107:2351-2361. 
Plantefaber, L.C., and Hynes, R.O. 1989. Changes in integrin receptors on oncogenically transformed cells. 
Ce// 56:281-290. 
Solowska, J., Guan, J.-L., Marcantonio, E.E., Trevithick, J.E., Buck, C.A., and Hynes, R.O. 1989- Expression of 
normal and mutant avian integrin subunits in rodent cells. J Cell Biol 109:853-861. 
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