can independently contribute to activation of E2 
transcription. 
The nature of the modification that alters E2F- 
binding properties and the effect of cooperative 
binding on E2F function are presently under study. 
Dr. Shenk is also James A. Elkins, Jr., Professor of 
Biology at Princeton University and Adjunct Profes- 
sor of Biochemistry at the University of Medicine 
and Dentistry of New Jersey, Robert Wood Johnson 
Medical School. 
PUBLICATIONS 
Books and Chapters of Books 
Shenk, T. 1989. Activation of adenovirus gene expression. In Concepts in Viral Pathogenesis III (Notkins, 
A.L., and Oldstone, M.B.A., Eds.). New^ York: Springer-Verlag, pp 58-63. 
Articles 
Chang, L.-S., Shi, Y, and Shenk, T. 1989- Adeno-associated virus P5 promoter contains an adenovirus ElA-in- 
ducible element and a binding site for the major late transcription factor, /yzro/ 63:3479-3488. 
Engel, D.A., Hardy, S., and Shenk, T. 1988. cAMP acts in synergy with ElA protein to activate transcription of 
the adenovirus early genes E4 and ElA. Genes Dev 2:1517-1528. 
Flint, J., and Shenk, T. Adenovirus ElA protein: paradigm viral transactivator. AnnuRev Genet 23:141-161. 
Hardy, S., Engel, D.A., and Shenk, T. An adenovirus early region 4 gene product is required for induction of 
the infection-specific form of cellular E2F activity. Genes Dev 3:1062-1074. 
Hasson, T.B., Soloway PD., Ornelles, D.A., Doerfler, W, and Shenk, T. 1989. Adenovirus LI 52- and 55- 
kilodalton proteins are required for assembly of virions. / Virol 63:3612-3621. 
Leppard, K.N., and Shenk, T. The adenovirus ElB 55 kd protein influences mRNA transport via an in- 
tranuclear effect on RNA metabolism. EMBO /8:2329-2336. 
Samulski, R.J., Chang, L.-S., and Shenk, T. Helper-free stocks of recombinant adeno-associated viruses: nor- 
mal integration does not require viral gene expression. J Virol 63:3822-3826. 
Schaack, J., and Shenk, T. 1988. Adenovirus terminal protein mediates efficient and timely activation of viral 
transcription. Curr Top Microbiol Immunol 144:185-190. 
Wilusz, J., Feig, D.I., and Shenk, T. 1988. The C proteins of heterogeneous nuclear ribonucleoprotein com- 
plexes interact with RNA sequences downstream of polyadenylation cleavage sites. Mol Cell Biol 8:4477- 
4483. 
Wilusz, J. , Pettine, S.M., and Shenk, T. 1989. Functional analysis of point mutations in the AAUAAA motif of 
the SV40 late polyadenylation signal. Nucleic Acids Res 17:3899-3908. 
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