dine motif found in the promoter regions of a num- 
ber of eukaryotic "housekeeping" genes, such as 
c-myc and genes encoding the insuHn and epider- 
mal growth factor (EGF) receptors. 
Utilizing Southwestern screening of an expres- 
sion library, Dr. George and her colleagues have 
identified cDNA clones encoding two of these puta- 
tive binding proteins, including one that binds to 
the homopurine-homopyrimidine domain. Because 
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the cKi-ras promoter region contains features 
shared by other housekeeping genes, efforts to un- 
derstand how transcription of this gene is governed 
should reveal factors regulating the expression of a 
class or set of such growth-control genes. 
Dr. George is also Associate Professor of Human 
Genetics at the University of Pennsylvania School of 
Medicine. 
Article 
Snyder, L.C., Trusko, S.P, Freeman, N., Eshleman, J.R., Fakharzadeh, S.S., and George, D.L. 1988. A gene am- 
plified in a transformed mouse cell line undergoes complex transcriptional processing and encodes a nu- 
clear protein. J Biol Chem 263:17150-17158. 
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