III. DNA Replication Studies. 
Dr. Lalande is working with a new class of com- 
pounds that inhibit cell growth. These compounds, 
which include the plant amino acid mimosine, ar- 
rest the cell cycle in the late Gl phase prior to the 
PUBLICATIONS 
onset of DNA synthesis. No cell cycle inhibitors that 
act at this point in the cell cycle had previously 
been described. The mimosine and related com- 
pounds will, therefore, offer a unique tool for ana- 
lyzing the key biochemical events that control the 
initiation of DNA synthesis in mammalian cells. 
Books and Chapters of Books 
Hejtmancik, J.F., Ward, P., Tantravahi, U., Hawley, E, Speer, J., Latt, S.A., Speer, M., and Pericak-Vance, M.A. 
1989. Genetic analysis: linkage, pedigrees, and Bayesian risk. In Molecular Genetics in Diseases of Brain, 
Nerve, and Muscle (Rowland, L.P., Wood, D.S., Schon, E.A., and DiMauro, S., Eds.). New York: Oxford Uni- 
versity Press, pp 191-207. 
Latt, S.A. , Nicholls, R.D. , Korf, B.R., Ringer, S., Neve, R.L., Kaplan, L., and Wharton, R. 1988. Chromosomal 
alterations in neurological disorders. In Discussions in Neurosciences: Molecular Genetic Mechanisms in 
Neurologic Disorders (Brown, P, Bolis, C.L., and Gajdusek, D.C., Eds.). Amsterdam: Elsevier, vol \, pp 22-31. 
Articles 
Covone, A.E., Kozma, R., Johnson, P.M., Latt, S.A., and Adinolfi, M. 1988. Analysis of peripheral maternal 
blood samples for the presence of placenta-derived cells using Y-specific probes and McAb H315. Prenat 
Diagn 8:591-607. 
Heartlein, M.W, Knoll, J.H.M., and Latt, S.A. 1988. Chromosome instability associated with human alphoid 
DNA transfected into the Chinese hamster genome. Mol Cell Biol 8:3611-3618. 
Heartlein, M.W, and Latt, S.A. 1989. Amplified inverted duplications within and adjacent to heterologous 
selectable DNA. Nucleic Acids Res 17:1697-1716. 
Higgins, M.J., Hansen, M.F., Cavenee, WK., and Lalande, M. 1989. Molecular detection of chromosomal trans- 
locations that disrupt the putative retinoblastoma susceptibility locus. Mol Cell Biol 9:1-5. 
Knoll, J.H.M., Nicholls, R.D. , Magenis, R.E., Graham, J.M., Jr., Lalande, M. , and Latt, S.A. 1989. Angelman and 
Prader-Willi syndromes share a common chromosome 15 deletion but differ in parental origin of the dele- 
tion. Am J Med Genet 32:285-290. 
Miiller, U., Lalande, M., Donlon, T.A., and Heartlein, M.W 1989- Breakage of the human Y-chromosome short 
arm between two blocks of tandemly repeated DNA sequences. Genomics 5:153-156. 
Nicholls, R.D. , Knoll, J.H.M., Glatt, K. , Hersh, J.H., Brewster, T, Graham, J., Wurster-Hill, D., Wharton, R., and 
Latt, S.A. 1989. Restriction fragment length polymorphisms within proximal 15q and their use in molecu- 
lar cytogenetics and the Prader-Willi syndrome. Am J Med Genet 33:66-77. 
Rudolph, N.S., and Latt, S.A. 1989. Flow cytometric analysis of X-ray sensitivity in ataxia telangiectasia. Mutat 
/?e5 211:31-41. 
Rudolph, N.S., Nagasawa, H., Little, J.B., and Latt, S.A. 1989- Identification of ataxia telangiectasia heterozy- 
gotes by flow cytometric analysis of X-ray damage. Mutat Res 211:19-29. 
Tantravahi, U., Nicholls, R.D. , Stroh, H., Ringer, S., Neve, R.L., Kaplan, L., Wharton, R., Wurster-Hill, D., 
Graham, J. M., Cantu, E.S., Frias, J.L., Kousseff, B.G., and Latt, S.A. 1989. Quantitative cahbration and use of 
DNA probes for investigating chromosome abnormalities in the Prader-Willi syndrome. Am J Med Genet 
33:78-87. 
Tantravahi, U., Stewart, G.D. , Van Keuren, M. , McNeil, G., Roy, S., Patterson, D., Drabkin, H., Lalande, M. , 
Kurnit, D.M., and Latt, S.A. 1988. Isolation of DNA sequences on human chromosome 21 by application of 
a recombination-based assay to DNA from flow-soned chromosomes. Hum Genet 79:196-202. 
Tsuji, H., Heartlein, M.W, and Latt, S.A. 1989. Disparate effects of 5-bromodeoxyuridine on sister-chromatid 
exchanges and chromosomal aberrations in Bloom syndrome fibroblasts. Mutat Res 198:241-253. 
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