iV von Recklinghausen Neurofibromatosis. 
found to reside on one 600 kb fragment of DNA, 
narrowing the region containing the gene to a seg- 
ment that is amenable to molecular investigation. A 
gene identified as the human homologue {EVI2) of 
a murine proto-oncogene, evi-2, was cloned and 
mapped between the translocation breakpoints; 
the pattern of expression of EVI2 in human tis- 
sues is consistent with a potential role for this gene 
in NFl. 
Dr. Peter O'Connell's group is seeking to iden- 
tify the gene responsible for peripheral neurofi- 
bromatosis (NFl). They have constructed a high- 
resolution genetic linkage map in the vicinity of 
the NFl locus near the centromere of chromosome 
17 and a physical map of cosmids in the region, as 
vital tools for the search. An important break- 
through was provided by the observation of trans- 
locations involving the appropriate region of chro- 
mosome 17 in the cells of two separate NFl 
patients. Both translocation breakpoints were 
Dr. White is also Professor of Human Genetics 
and of Cellular, Viral, and Molecular Biology at the 
University of Utah School of Medicine. 
PUBLICATIONS 
Books and Chapters of Books 
Odelberg, S., and White, R. 1989. Repetitive DNA: molecular structure, polymorphism, and forensic applica- 
tions. \nDNA and Other Polymorphisms of Forensic Sciences (Lee, H.C., and Gaensslen, R.E., Eds.). Chi- 
cago: Yearbook Medical, pp 32-43. 
White, R., and Lalouel, J.-M. 1989. Genetic markers in medicine. In The Molecular Basis of Inherited Disease 
(Scriver, C.R., Beaudet, A.L. , Sly, WS., and VaUe, D. , Eds.). New York: McGraw-Hill, pp 277-290. 
Baker, S., Fearon, E., Nigro, J., Hamilton, S., Preisinger, A., Jessup, J., van Tuinen, R, Ledbetter, D., Barker, D., 
Nakamura, Y , White, R. , and Vogelstein, B. 1989. Chromosome 17 deletions and p53 mutations in col- 
orectal carcinomas. Science 244:217-221. 
Byerley, W, O'Connell, R , Lalouel, J.-M. , Mellon, C, Nakamura, Y , Leppen, M. , and White, R. 1989. Mapping 
genes for manic-depression and schizophrenia with DNA markers. Trends Neurosci 12:46-48. 
Drayna, D.T., Hegele, R.A. , Hass, RE., Emi, M. , Wu, L.L., Eaton, D.L., Lawn, R.M., Williams, R.R., White, R.L. , 
and Lalouel, J.-M. 1988. Genetic linkage between lipoprotein(a) phenotype and a DNA polymorphism in 
the plasminogen gene. Genomics 3:230-236. 
Emi, M ., Wu, L.L., Robertson, M.A. , Myers, R.L. , Hegele, R.A. , Williams, R.R., White, R. , and Lalouel, J.-M. 
1988. Genotyping and sequence analysis of apolipoprotein E isoforms. Genomics 3:373-379. 
Fountain, J.W, Wallace, M.R. , Brereton, A.M., O'Connell, R , White, R.L. , Rich, D.C., Ledbetter, D.H., Leach, 
R.J., Fournier, R.E.K., Menon, A.G., Gusella, J.F., Barker, D., Stephens, K., and Collins, F.S. 1989. Physical 
mapping of the von Recklinghausen neurofibromatosis region on chromosome 17. Am f Hum Genet 
44:58-67. 
Fujimoto, M., Fults, D., Thomas, G., Nakamura, Y, Heilbrun, M., White, R., Story, J., Naylor, S., Kagan-Hallet, 
K., and Sheridan, P. 1989. Loss of hetero2ygosity on chromosome 10 in human glioblastoma multiforme. 
Genomics 4:210-214. 
Gatti, R., Berkel, I., Boder, E., Braedt, G., Charmley P., Concannon, P., Ersoy, F., Fouroud, T, Jaspers, N., 
Lange, K., Lathrop, M., Leppert, M., Nakamura, Y, O'Connell, R, Raterson, M., Salser, W, Sana, O., Silver, J., 
Sparkes, R., Susk, E., Weeks, D., Wei, S., White, R., and Yoder, F. 1988. Localization of an ataxia-telangiecta- 
sia gene to chromosome llq22-23. Nature 336:577-580. 
Lathrop, M., Nakamura, Y, O'Connell, R, Leppert, M., Woodward, S., Lalouel, J.-M., and White, R. 1988. A 
mapped set of genetic markers for human chromosome 9. Genomics 3:361-366. 
Articles 
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