vectors that upon transfection into embryonic stem 
(ES) or pre-B cell lines allow efficient isolation of 
variants containing a disrupted N-myc gene. Re- 
lated constructs are now being used to disrupt 
both N-myc copies in these lines. A variety of trans- 
genic mouse strains or cell lines harboring normal 
or variant (both with respect to expression or struc- 
PUBLICATIONS 
ture) N-myc genes were created to complement po- 
tential mouse or cell lines in which the endoge- 
nous N-myc genes are disrupted. 
Dr. Alt is also Professor of Biochemistry and Mi- 
crobiology at Columbia University College of Physi- 
cians and Surgeons. 
Books and Chapters of Books 
Alt, F.W 1989. Genetically programmed and adaptive genome plasticity in mammalian cells. Immunoglobulin 
genes and gene amplification. In Molecular Genetics in Diseases of Brain, Nerve, and Muscle (Rowland, 
LP, Wood, D.S., Schon, E.A., and DiMauro, S., Eds.). New York: Oxford University Press, pp 85-101. 
Ferrier, R , Krippl, B., Blackwell, K. , Suh, H. , Winoto, A., Hood, L., Costantini, P., and Alt, EW 1989. Control of 
VDJ recombinase activity: tissue-specific assembly of transgenic T cell receptor variable region gene seg- 
ments. In Cellular Basis of Immune Modulation (Kaplan, J.G., Green, D.R., and Bleackley, R.C., Eds.). 
New York: Liss, pp 189-199. 
Logtenberg, T., Young, E, van Es, J., Gmeling-Meyling, F., Berman, J., and Alt, E.W 1989. Frequency of V^^-gene 
utilization in human EBV-transformed B cell lines. The most Jj^-proximal Vj^ gene segment encodes au- 
toantibodies. In T-Cell Activation in Health and Disease: Disorders of Immune Regulation, Infection, and 
Autoimmunity (Feldmann, M., Maini, R., and Woody, J.N. , Eds.). New York: Academic, pp 203-213. 
Lutzker, S., and Alt, F.W 1989. Immunoglobulin heavy chain class-switching. In Mobile DNA (Berg, D.E., and 
Howe, M., Eds.). Washington, DC: ASM, pp 691-712. 
Rathbun, G., Berman, J., Yancopoulos, G.D., and Alt, F.W 1989. Organization and expression of the mamma- 
lian heavy chain variable region locus. In Immunoglobulin Genes (Alt, F.W, Honjo, T., and Rabbits, T.H., 
Eds.). London: Academic, pp 63-90. 
Articles 
Alt, F.W, Ferrier, R, Malynn, B., Lutzker, S., Rothman, P., Berman, J., Blackwell, K., Mellis, S., Pollock, R., 
Furley, A., Rathbun, G., Yancopoulos, G.D., Logtenberg, T, Morrow, M., Cook, W, Heinke, B., and Suh, H. 
1989. Control of recombination events during lymphocyte differentiation. Heavy chain variable region 
gene assembly and heavy chain class switching. Ann NY Acad Sci 546:9-24. 
Blackwell, T.K., and Alt, F.W 1989. Mechanism and developmental program of immunoglobulin gene rear- 
rangement in mammals. Annu Rev Genet 23:605-636. 
Blackwell, T.K., and Alt, F.W 1989. Molecular characterization of the lymphoid V(D)J recombination activity. 
J Biol Chem 264: 10327-10330. 
Blackwell, T.K., Malynn, B.A., Pollock, R.R., Ferrier, E, Covey, L.R., Fulop, G.M., Phillips, R.A., Yancopoulos, 
G.D., and Alt, F.W 1989. Isolation of scid pre-B cells that rearrange kappa light chain genes: formation of 
normal signal and abnormal coding joints. EMBO / 8:735-742. 
Campbell, G.R., Zimmerman, K., Blank, R.D., Alt, F.W, and D'Eustachio, E 1989. Chromosomal location of 
N-myc and L-myc genes in the mouse. Oncogene Res 4:47-54. 
CoUum, R.G., DePinho, R., Mellis, S., Thiele, C, Israel, M., and Alt, F.W 1989. A novel gene expressed specif- 
ically in neuroepitheliomas and related tumors. Cancer Cells 7:113-116. 
Dildrop, R., Ma, A., Zimmerman, K., Hsu, E., Tesfaye, A., DePinho, R., and Alt, F.W 1989. IgH enhancer-medi- 
ated deregulation of N-myc gene expression in transgenic mice: generation of lymphoid neoplasias that 
lack c-myc expression. EMBO / 8: 112 1-1 128. 
Dildrop, R., Zimmerman, K., DePinho, R.A., Yancopoulos, G.D. , Tesfaye, A., and Alt, F.W 1988. Differential ex- 
pression of myc-family genes during development: normal and deregulated N-myc expression in transge- 
nic mice. Curr Top Microbiol Immunol 141:100-109. 
Continued 
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