not simple to introduce genes into neurons, be- 
cause these cells are postmitotic. Dr. Fishman's lab- 
oratory has shown, in collaboration with Dr. Philip 
Leder (HHMI, Harvard Medical School), that the 
promoter of the calcitonin gene-related peptide 
(CGRP) gene functions in transgenic mice to direct 
expression of transgenes to subpopulations of sen- 
sory neurons and to the thyroid C cells. A variety of 
oncogenes have been found to be without effect 
when introduced in this manner. Dr. Manfred 
Baetscher has found that the SV40 large T antigen, 
however, not only causes tumors of the C cells, but 
PUBLICATIONS 
also perturbs neuronal function, most evident phe- 
notypically as an ataxic gait. Preliminary pathologi- 
cal analysis suggests that lysosomal debris accumu- 
lates within DRG neurons. Dr. Fishman and his 
colleagues are studying this inherited neuropathy 
to investigate how a dominant oncogene, which 
regulates cell cycle in other cells, perturbs function 
in postmitotic neurons. 
Dr. Fishman is also Associate Professor of Medi- 
cine at Harvard Medical School and Assistant Physi- 
cian at Massachusetts General Hospital. 
Books and Chapters of Books 
Fishman, M.C. 1989. Genes of neuronal growth and plasticity. In Assembly of the Nervous System 
(Landmesser, L., Ed.). New York: Liss, pp 247-257. 
Articles 
de la Monte, S.M., Federoff H.J., Ng, S.-C., Grabczyk, E., and Fishman, M.C. 1989. GAP-43 gene expression 
during development: persistence in a distinctive set of neurons in the mature central nervous system. Dev 
Brain Res 46:161-168. 
Federoff, H.J., Grabczyk, E., and Fishman, M.C. 1988. Dual regulation of GAP-43 gene expression by nerve 
growth factor and glucocorticoids. J Biol Chem 263:19290-19295. 
Ng, S.-C, Perkins, E., Conboy, G., Perrimon, N., and Fishman, M.C. 1989- KDrosophila gene expressed in the 
embryonic CNS shares one conserved domain with the mammalian GAP-43. Development 105:629-638. 
Zuber, M.X., Goodman, D.W, Karns, L.R., and Fishman, M.C. 1989. The neuronal growth-associated protein 
GAP-43 induces filopodia in non-neuronal cells. Science 244:1193-1195. 
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