leagues are continuing the characterization of gene 
products expressed exclusively in this developmen- 
tal pathway. 
The complete understanding of many aspects of 
neurogenesis in the olfactory system would be 
greatly aided by the availability of cell lines capable 
of displaying these differentiation processes in cul- 
ture. Transgenic mouse lines carrying the SV40 T 
antigen oncogene under the control of an olfactory 
neuron-specific promoter have been generated. 
These animals develop neuroblastomas in the olfac- 
tory region. Brian Largent has successfully gener- 
PUBLICATIONS 
ated cell lines from these tumors; some of these ex- 
press neuron-specific gene products that Dr. Reed 
and his colleagues had previously identified. Pres- 
ently the laboratory is attempting to expand the 
repertoire of mature neuronal markers expressed 
by these cells by altering the cell culture condi- 
tions. 
Dr. Reed is also Associate Professor in the Depart- 
ments of Molecular Biology and Genetics and of 
Neuroscience at The Johns Hopkins University 
School of Medicine. 
Articles 
Blatt, C, Eversole-Cire, P, Cohn, VH., Zollman, S., Fournier, R.E.K., Mohandas, L.T, Nesbitt, M., Lugo, T., 
Jones, D.T. , Reed, R.R. , Weiner, L.P., Sparkes, R.S., and Simon, M.I. 1988. Chromosomal localization of 
genes encoding guanine nucleotide-binding protein subunits in mouse and human. Proc Natl Acad Set 
USA 85:7642-7646. 
Jones, D.T, Barbosa, E., and Reed, R.R. 1988. Expression of G-protein a subunits in rat olfactory neu- 
roepithelium: candidates for olfactory signal transduction. Cold Spring Harb Symp Quant Biol 53:349- 
353. 
Jones, D.T, and Reed, R.R. 1989. G^j^: an olfactory neuron specific-G protein involved in odorant signal 
transduction. Science 244:790-795. 
Krupinski, J., Coussen, F., Bakalyar, H.A., Tang, W-J., Feinstein, PG., Orth, K., Slaughter, C. , Reed, R.R. , and 
Gilman, A.G. 1989. Adenylyl cyclase amino acid sequence: possible channel- or transporter-like structure. 
Science 244:l55S-\564. 
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