ing the past year, significant progress has been 
made in two relevant areas. 
First, the distribution of the mineralocorticoid re- 
ceptor throughout the brain has been determined 
using in situ hybridization, and the cis-trans- 
cotransfection assay has been used to show that 
mineralocorticoids and glucocorticoids may interact 
"with the same promoter elements to expand the 
dynamic range of such elements to steroid hor- 
mones. These results may have important implica- 
tions for understanding neural mechanisms under- 
lying salt appetite, an essential component of 
ingestive behavior. 
Second, in collaboration with Dr. Michael G. 
PUBLICATIONS 
Rosenfeld (HHMI, University of California at San 
Diego), a family of transcription factors that may 
play an important role in the development of the 
nervous system has been identified. These nuclear 
proteins share a POU-domain, and some members 
also appear to be involved in establishing the phe- 
notype of cells in other tissues as well, including 
the anterior pituitary, immune system, gonads, and 
kidney. 
Dr. Swanson is also Senior Member at The Salk 
Institute for Biological Studies and Adjunct Profes- 
sor of Neurosciences at the University of California 
at San Diego. 
Articles 
Arriza, J.L., Simerly, R.B., Swanson, L.W, and Evans, R.M. 1988. The neuronal mineralocorticoid receptor as a 
mediator of glucocorticoid response. Neuron 1:887-900. 
He, X., Treacy M.N., Simmons, D.M., Ingraham, H., Swanson, L.W, and Rosenfeld, M.G. 1989. Expression of a 
large family of POU-domain regulatory genes in mammalian brain development. Nature 340:35-42. 
Ingraham, H.A., Chen, R., Mangalam, H.J., Elsholtz, H.E, Elynn, S.E., Lin, C.R., Simmons, D.M., Swanson, L., 
and Rosenfeld, M.G. 1988. A tissue-specific transcription factor containing a homeodomain specifies a pi- 
tuitary phenotype. Cell 55:519-529. 
Ju, G., and Swanson, L.W 1989. Studies on the cellular architecture of the bed nuclei of the stria terminalis 
in the rat. I. Cytoarchitecture. J Comp Neurol 280:587-602. 
Ju, G., Swanson, L.W, and Simerly, R.B. 1989. Studies on the cellular architecture of the bed nuclei of the 
stria terminalis in the rat. II. Chemoarchitecture. J Comp Neurol 280:603-621. 
Rho, J.-H., and Swanson, L.W 1989. A morphometric analysis of functionally defined subpopulations of neu- 
rons in the paraventricular nucleus of the rat with observations on the effects of colchicine. / Neurosci 
9:1375-1388. 
Simerly, R.B., Young, B.J., Capozza, M.A., and Swanson, L.W 1989. Estrogen differentially regulates neu- 
ropeptide gene expression in a sexually dimorphic olfactory pathway. Proc Natl Acad Sci USA 86:4766- 
4770. 
Swanson, L.W , Simmons, D.M. , Hofmann, S.L., Goldstein, J.L., and Brown, M.S. 1988. Localization of mRNA 
for low density lipoprotein receptor and a cholesterol synthetic enzyme in rabbit nervous system by in 
situ hybridization. Proc Natl Acad Sci USA 85:9821-9825. 
Wada, E., Wada, K., Boulter, J., Deneris, E., Heinemann, S., Patrick, J., and Swanson, L.W 1989. The distribu- 
tion of a2, a3, a4, and P2 neuronal nicotinic receptor subunit mRNAs in the central nervous system. A hy- 
bridization histochemical study in the rat. J Comp Neurol 284:314-335. 
554 
