the gene for the Crotalus atrox enzyme, the most 
studied crystal structure of this laboratory. Sys- 
tems for overexpressing homologous pancreatic en- 
zymes exist and will be adapted to this protein, 
with a view to testing mechanistic proposals by di- 
rected mutational changes in the amino acid se- 
quence. 
Dr. Sigler is also Professor of Molecular Biophys- 
ics and Biochemistry at Yale University. 
PUBLICATIONS 
Books and Chapters of Books 
Marmorstein, R., and Sigler, EB. 1989. Structure and mechanism of the trp repressor/operator system. In 
Nucleic Acids and Molecular Biology (Eckstein, R, and Lilley, D.M.J., Eds.). Berlin: Springer-Verlag, vol 3, 
pp 56-78. 
Barlow, P.N., Lister, M.D., Sigler, EB., and Dennis, E.A. 1988. Probing the role of substrate conformation in 
phospholipase A2 action on aggregated phospholipids using constrained phosphatidylcholine analogues. 
JBiolChem 263:12954-12958. 
Barlow, EN., Vidal, J.-C, Lister, M.D., Hancock, A.J., and Sigler, EB. 1988. Synthesis and some properties of 
constrained short-chain phosphatidylcholine analogues: (+)- and (-)-(l,3/2)-l-0-(phosphocholine)-2,3-0- 
dihexanoylcyclopentane-l,2,3-triol. Chem Phys Lipids 46:157-164. 
Freedman, L.E, Luisi, B.F., Korszun, Z.R., Basavappa, R., Sigler, EB., and Yamamoto, K.R. 1988. The function 
and structure of the metal coordination sites within the glucocorticoid receptor DNA binding domain. Na- 
ture 334:543-546. 
Lawson, C.L., and Sigler, EB. 1988. The structure of the trp pseudorepressor at 1.65A shows why indole pro- 
pionate acts as a trp inducer. Nature 333:869-871. 
Lawson, C.L., Zhang, R.-G., Schevitz, R.W, Otwinowski, Z., Joachimiak, A., and Sigler, PB. 1988. Flexibility of 
the DNA-binding domains of trp repressor. Proteins 3:18-31. 
Marmorstein, R.Q., and Sigler, PB. 1989. Stereochemical effects of L-tryptophan and its analogues on trp 
repressor's affinity for operator-DNA./fi/o/ Chem 264:9149-9154. 
Otwinowski, Z., Schevitz, R.W, Zhang, R.-G., Lawson, C.L., Joachimiak, A., Marmorstein, R.Q., Luisi, B.F., and 
Sigler, PB. 1988. Crystal structure of trp repressor/operator complex at atomic resolution. Nature 
335:321-329. 
Wagner, T, Sigler, PB. , and Gross, M. 1989. Mechanism of inhibition of eukaryotic translational initiation by 
the trinucleotide ApUpG. FEES Lett 250:147-152. 
Articles 
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