855. Macdonald, RM. , and Struhl, G. 1988. Cis-acting sequences responsible for anterior localization of bicoid mRNA in Drosophila 
embryos. Nature 336:595-598. 
856. MacGregor, G.R., and Caskey, C.T. 1989- Construction of plasmids that express E. colt p-galactosidase in mammalian cells. 
Nucleic Acids Res 17:2365. 
857. MacGregor, G.R., Nelson, D.L. , Chang, S.M.W, and Caskey, C.T. 1989. Gene replacement therapy: the example of Lesch-Nyhan 
syndrome. In Molecular Genetics of Diseases of Brain, Nerve, and Muscle (Rowland, L.E, Wood, D.S., Schon, E.A., and 
DiMauro, S., Eds.). New York: Oxford University Press, pp 417-425. 
858. Maddalena, A. . Sosnoski, P.M. , Berry, G.T., and Nussbaum, R.L. 1988. Mosaicism for an intragenic deletion in a boy with mild 
ornithine transcarbamylase deficiency. N Engl J Med 319:999-1003. 
859. Maddalena, A. , Spence, J.E., O'Brien, WE. , and Nussbaum R.L. 1988. Characterization of point mutations in the same arginine 
codon in three unrelated patients with ornithine transcarbamylase deficiency. / Clin Invest 82:1353-1358. 
860. Madison, E.L., Goldsmith, E.J., Gerard, R.D., Gething, M.J., and Sambrook, J. 1989. Serpin-resistant mutants of human tissue- 
type plasminogen activator. Nature 339:721-724. 
861. Mahdavi, V, Lompre, A.M., Chambers, A.E, and Nadal-Ginard, B. 1988. Regulation and structure of the a- and (3-cardiac myosin 
heavy chain genes. \n Pediatric Cardiology: Atrioventricular Septal Defects (Jimenez, M.Q., and Martinez, M.A., Eds.). Madrid: 
Ediciones Norma, pp 369-387. 
862. Mahdavi, V, and Nadal-Ginard, B. 1989. Molecular basis of cardiac contractility. Heart Failure 5:135-140. 
863. Malim, M.H. , Bohnlein, S. , Hauber, J. , and Cullen, B.R. 1989. Functional dissection of the HIV-1 Rev rraws-activator— derivation 
of a trans-dominunt repressor of Rev function. Cell 58:205-214. 
864. Malim, M.H. , Fenrick, R. , Ballard, D.W , Hauber, J. , Bohnlein, E. , and Cullen, B.R. 1989. Functional characterization of a com- 
plex protein-DNA-binding domain located within the human immunodeficiency virus type 1 long terminal repeat leader re- 
gion. /V?ro/ 63:3213-3219. 
865. Malim, M.H. , Hauber, J. , Fenrick, R. , and Cullen, B.R. 1988. Immunodeficiency virus rev ?raw5-activator modulates the expres- 
sion of the viral regulatory genes. Nature 335: 181-183. 
866. Malim, M.H. , Hauber, J. , Le, S.-Y, Maizel, J.V, and Cullen, B.R. 1989. The HIV-1 rev frans-activator acts through a structured tar- 
get sequence to activate nuclear export of unspliced viral mRNA. Nature 338:254-257. 
867. Mandel, J.-L., Willard, H.F., Nussbaum, R.L. , Davies, K.E., Puck, J.M., and Romeo, G. 1989. Report of the committee on the ge- 
netic constitution of the X chromosome. Cytogen Cell Genet 51:384-437. 
868. Mandel, J.-L., Willard, H.F., Nussbaum, R.L. , Davies, K.E., and Romeo, G. 1988. Report of the committee on the genetic consti- 
tution of the X chromosome. Cytogen Cell Genet 49:107-128. 
869. Mangalam, H J., Albert, VR. , Ingraham, H.A. , Kapiloff, M., Wilson, L., Nelson, C, Elsholtz, H., and Rosenfeld, M.G. 1989. A pitu- 
itary POU domain protein, Pit-1, activates both growth hormone and prolactin promoters transcriptionally. Genes Dev 3:946- 
958. 
870. Mansour, S.L. , Thomas, K.R. , and Capecchi, M.R. 1988. Disruption of the proto-oncogene int-2 in mouse embryo-derived stem 
cells: a general strategy for targeting mutations to non-selectable genes. Nature 336:348-352. 
871. Manz, J., Denis, K. , Witte, O.N. , Brinster, R., and Storb, U. 1988. Feedback inhibition of immunoglobulin gene rearrangement 
by membrane but not by secreted |x heavy chains. J Exp Med 168; 1363-1382. 
872. Marchuk, D. , and Collins, F.S. 1988. p"VAC-RC, a yeast artificial chromosome vector for cloning DNA cut with infrequently cut- 
ting restriction endonucleases. Nucleic Acids Res 16:7743. 
873. Marion, T.N., Bothwell, A.L.M. , Briles, D.E., and janeway, C.A.,Jr. 1989. IgG anti-DNA autoantibodies within an individual auto- 
immune mouse are the products of clonal selection. / Immunol 142:4269-4274. 
874. Markman, J., Lo, D., Naji, A., Palmiter, R.D. , Brinster, R.L., and Heber-Katz, E. 1988. Antigen presenting function of class II MHC 
expressing pancreatic beta cells. Nature 336:476-479. 
875. Marmorstein, R., and Sigler, PB. 1989. Structure and mechanism of the trp repressor/operator system. In Nucleic Acids and 
Molecular Biology (Eckstein, F, and Lilley, D.MJ., Eds.). Berlin: Springer-Verlag, vol 3, pp 56-78. 
876. Marmorstein, R.Q., and Sigler, RB. 1989. Stereochemical effects of L-tryptophan and its analogues on trp repressor's affinity for 
operator-DNA.y Biol Chem 264 :9 149-9 1 54. 
877. Marrack, P , and Kappler, J. 1989. Antigen recognition and tolerance. Consequences for the T cell repertoire. In Current Com- 
munications in Molecular Biology. Perspectives on the Molecular Biology and Immunology of the Pancreatic B Cell (Hanahan, 
D., McDevitt, H.O., and Cahill, G.R, Jr. , Eds.). Cold Spring Harbor, NY: Cold Spring Harbor, p 169. 
878. Marrack, R , and Kappler, J.W 1988. The T-cell repertoire for antigen and MHC. Immunol Today 9:308. 
879. Marrack, R , McCormack, J. , and Kappler, J. 1989. Presentation of antigen, foreign histocompatibility complex proteins and self 
by thymus cortical epithelium. Nature 338:503-505. 
880. Manh, J.D. , Lewis, D.B., Cooke, M.R, Mellins, E.D., Gearn, M.E., Samelson, L.E., Wilson, C.B., Miller, A.D., and Perlmutter, R.M. 
1988. Lymphocyte activation provokes modification of a lymphocyte-specific protein tyrosine kinase (p56''^*). J Immunol 
142:2430-2437. 
881. Martin, A.O., Northrup, H., Ledbetter, D.H., Trask, B., van den Engh, G., Le Beau, M.M., Beaudet, A.L. , Gray, J.W, Sekhon, G., 
Continued 
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