W. B. HOOD, JR. AND J. C. NORMAN 
49 
sions have been carried out. During this period 
the animal gave no evidence of discomfort or a 
painful reaction. This method deserves further 
exploration in the future, and if pain reactions 
are obtained, the preparation will be eminently 
suitable for studying the total clinical spectrum 
of acute coronary occlusion in an animal model 
which closely simulates the syndrome in man. 
REFERENCES 
1. Harris, A. S. Delayed development of ventricular 
ectopic rhythms following experimental coronary 
occlusion. Circulation 1:1318-1328, 1950. 
2. ViNEBERG, A., Mahanti, B., and Litvak, J. Exper- 
imental gradual coronary artery constriction by 
ameroid constrictors. Surgery 47 :765-771, 1960. 
3. Agress, C. M., Rosenberg, M. J., Jacobs, H. I., 
Binder, M. J., Schneiderman, A., and Clark, W. 
G. Protracted shock in the closed-chest dog follow- 
ing coronary embolization with graded micro- 
spheres. Amer. J. Physiol. 170:536-549, 1952. 
4. Hammer, J., and Pisa, Z. A method of isolated, 
gradual occlusion of a main branch of a coronary 
artery in closed-chest dogs. Amer. Heart J. 
64:67-70, 1962. 
5. GoLDPARB, D., and Gott, V. L. Cardiovascular al- 
terations during declining and steady-state low car- 
diac output secondary to coronary insufficiency in 
the dog. J. Thorac. Cardiovasc. Surg. 56:578-589, 
1968. 
6. Weisse, a. B., Lehan, P. H., Ettinger, P. 0., 
MoscHOS, C. B., and Regan, T. J. The fate of ex- 
perimentally induced coronary artery thrombosis. 
Am. J. Cardiol. 23:229-237, 1969. 
7. Lluch, S., Moguilevsky, H. C, Pietra, G., Shaf- 
fer, A. B., HiRSCH, L. J., and Fishman, A. P. A 
reproducible model of cardiogenic shock in the 
dog. Circulation 39:205-218, 1969. 
8. Kezdi, p., Marshall, W. J., Jr., and Stanley, E. 
L. Hemodynamic and biochemical measurements 
in experimental myocardial infarction. Am. J. Car- 
diol. 19:135, 1967. 
9. Chimoskey, J. E., Szentivanyi, M., Zakheim, R., 
and Barger, A. C. Temporary coronary occlusion 
in conscious dogs: Collateral flow and electrocar- 
diogram. Am. J. Physiol. 212:1025-1032, 1967. 
10. Khouri, E. M., Gregg, D. E., and Lowensohn, 
H. S. Flow in the major branches of the left coro- 
nary artery during experimental coronary insuffi- 
ciency in the urianesthetized dog. Circ. Res. 
23:99-109, 1968. 
11. Hood, W. B., Jr., Covelli, V. H., Abelmann, W. 
H., and Norman, J. C. Persistence of contractile 
behavior in acutely ischemic myocardium. Cardio- 
vasc. Res. 3:249-260, 1969. 
12. Hood, W. B., Jr., Covelli, V. H., and Norman, J. 
C. Acute coronary occlusion in pigs: Effects of 
acetyl strophanthidin. Cardiovasc. Res. 3:441-446, 
1969. 
13. Molokhia, F. a., Asimacopoulos, P. J., Kumar, 
P., Hood, W. B., Jr., and Norman, J. C. Con- 
trolled production of left ventricular failure in in- 
tact calves using implanted coronary occluders. 
Ann. Thor. Surg. 10; 503-511, 1970. 
14. Hood, W. B., Jr., Joison, J., Kumar, R., Katay- 
ama, I., Neiman, R. S., and Norman, J. C. Exper- 
imental myocardial infarction. I. Production of left 
ventricular failure by gradual coronary occlusion in 
intact conscious dogs. Cardiovasc. Res. 4:73-83, 
1970. 
15. Joison, J., Kumar, R., Hood, W. B., Jr., and Nor- 
man, J. C. An implantable system for producing 
left ventricular failure for circulatory assist device 
evaluation. Trans. Amer. Soc. Art. Int. Organs 
15:417-422, 1969. 
16. Kumar, R., Hood, W. B., Jr., Joison, J., Norman, 
J. C, and Abelmann, W. H. Experimental my- 
ocardial infarction. II. Acute depression and subse- 
quent recovery of left ventricular function: Serial 
measurements in intact conscious dogs. J. Clin. In- 
vest. 49:55-62, 1970. 
17. Hood, W. B., Jr., Bianco, J. A., Kumar, R., and 
Whiting, R. B. Experimental myocardial infarc- 
tion. IV. Reduction of left ventricular compliance 
in the healing phase. J. Clin. Invest. 49:1316-1323, 
1970. 
18. Kumar, R., Hood, W. B., Jr., Joison, J., Gil- 
MOUR, D. P., Norman, J. C, and Abelmann, W. 
H. Experimental myocardial infarction. VI. 
Efficacy and toxicity of digitalis in acute and heal- 
ing phase in intact conscious dogs. J. Clin. Invest. 
49:358-364, 1970. 
19. Kumar, R., Sharma, G.V.R.K., Molokhia, F. A., 
Norman, J. C, Inamdar, A. N., Messer, J. V., 
Abelmann, W. H., and Hood, W. B., Jr. Experi- 
mental myocardial infarction. X. Efficacy of gluca- 
gon in acute and healing phase in intact conscious 
dogs: Effects on hemodynamics and myocardial 
oxygen consumption. Circulation 45:55-64, 1972. 
20. Kumar, R., Joison, J., Gilmour, D. P., Molokhia, 
F. A., Pegg, C. a. S., and Hood, W. B., Jr. Exper- 
imental myocardial infarction. VIII. Chronotropic 
augmentation of cardiac function in left ventricular 
failure of acute and healing stages in intact con- 
scious dogs. J. Clin. Invest. 50:217-225, 1971. 
21. Hood, W. B., Jr., Singh, J. B., Abelmann, W. H., 
and POLANSKY, B. J. Positive inotropic effects of 
phentolamine in left ventricular failure due to ex- 
perimental myocardial infarction. Circulation 34 
(Supp. II) : 127, 1971. 
22. Hood, W. B., Jr. Salvage of myocardium in acute 
ischemia. Circulation 43:11-13, 1971. 
23. Gilmour, D. P., Hood, W. B., Jr., Kumar, R., 
Joison, J., Norman, J. C, and Abelmann, W. H. 
Hyperbaric oxygenation in acute myocardial in- 
farction in intact conscious dogs. Fed. Proc. 
29:586, 1970. 
