8 
INTRODUCTION 
interests of clinical medicine or humanity in 
general. It is incumbent on us as researchers 
to assume the leadership which we have failed 
to acknowledge as individuals. This message was 
spelled out to us very clearly by the acknowl- 
edged spokesman for biomedical research in the 
Congress, Senator Magnuson, when in speak- 
ing at the recent meeting of the AAMC he said, 
"These are questions for which we must 
find positive answers. Most of these questions 
are still in your court. Not you alone but you 
collectively. You are in positions of leadership 
in these matters. You can exercise that leader- 
ship positively or through default pass the 
ball to others. If you fail to act, then others 
perhaps less capable than you may design 
imperfect answers." 
In conclusion, I would like to say that we, as 
researchers, must strive to develop new, more 
applicable animal models, to use current models 
to their maximum capacity, and to insure the 
proper care and handling of all our research 
animals. We must remember that animal models 
are a means to study human diseases and that 
the study of basic physiological parameters of 
both healthy and diseased states and the meth- 
ods and techniques of monitoring them requires 
improved data from research animals. 
