TABLE OF CONTENTS 
Page 
FOREWORD : iii 
PREFACE V 
REVIEW BOARD ix 
ACKNOWLEDGEMENT x 
TABLE OF CONTENT xi 
Chapter I— INTRODUCTION 
The Role of Animal Research in Clinical Medicine 
Robert Van Citters 3 
Chapter II— CARDIAC MODELS 
Animal Models of Atherosclerosis 
Thomas B. Clarkson 11 
Animal Research in Shock 
R. M. Hardaway, III 21 
Observations on Experimental Myocardial Infarctions in Dogs 
Jacob I. Hirsch, Fritz Streuli and Fred Gorstein 29 
Animal Models of Myocardial Infarction: Current Limitations and Future Promise 
W. B. Hood, Jr. and J. C. Norman 41 
Turkey Round Heart Disease: A Model Cardiomyopathy 
E. F. Jankus, N. A. Staley and G. R. Nor en 53 
Studies of a Cardiogenic Shock Model 
P. Kezdi, S. N. Misra, R. K. Kordenat, and T. J. Smith 61 
Biventricular Mechanical Bypass; Physiological Studies During Induced Ventricular 
Failure 
C. Grant LaFarge and W. F. Bernhard 75 
Model of Advanced Coronary Atherosclerosis, Myocardial Infarction and Sudden 
Death with Lethal Arrhythmias in Swine 
K. T. Lee, J. Jarmolych, D. N. Kim and W. M. Lee 93 
Experimental Myocardial Infarction in Nonhuman Primates 
M. R. Malinow, J. D. Hill, M. Lees, W. P. McNulty and A. J. Ochsner, III 105 
Canine Coronary Insufficiency Models for Evaluating Systems for Circulatory 
Support 
/. Rosensweig and S. Chatterjee 119 
ll Pulmonary Artery Constriction in the Cat : A Model for Ventricular Hypertrophy 
■ and Congestive Heart Failure 
I J. F. Spann, Jr. and G. M. Lemole 141 
I Experimental Myocardial Infarction by Closed Chest Technique 
I E. L. Stanley, P. Kezdi and R. K. Kordenat 157 
I Left Ventricular Failure and Cardiogenic Shock Following Acute Myocardial 
■ Infarction : A Correlation of Clinical and Experimental Observations 
I K. T. Weber, R. A. Ratshin, C. E. Rackley and R. 0. Russell, Jr 169 
P Proteases and Chemical Mediators in Acute Coronary Occlusion in the Dog 
H. J. Wilkens, R. Steger and N. Back 179 
