viii 
PREFACE 
ments. The discussion is directed to the regula- 
tions required by law, the recommendations in- 
cluded in the NIH Guidelines, implementation 
of these guidelines, and the practical considera- 
tions in achieving improved laboratory investi- 
gations. It is apparent from the discussions and 
information presented by both the research in- 
vestigator and those interested in animal wel- 
fare that enormous strides have been made in 
bringing into balance the various approaches 
and philosophies concerning animal research. 
I hope that the conference on research ani- 
mals in medicine and this text will stimulate 
new, imaginative, and creative efforts in this 
field, and foster contacts and interactions be- 
tween those who search for knowledge and 
those who must use the results in the treatment 
and prevention of disease. 
Lowell T. Harmison, Ph.D., Editor 
Special Assistant to The Director 
National Heart and Lung Institute 
National Institutes of Health 
