74 CARDIAC 
of embolization or lactate or myocardial oxygen 
consumption ? 
Dr. Kezdi: We have not done coronary flow 
measurements in these animals. Myocardial 
oxygen consumption decreased and lactate pro- 
duction (excess lactate) markedly increased. It 
MODELS 
was of interest to us that reversal of this did 
occur only with combined isoproternol and nore- 
pinephrine treatment. Also, as you have seen, 
the dose of both drugs was about half of that 
which was needed to produce changes when used 
alone. 
