96 
CARDIAC MODELS 
Figure 1. — Gross photograph of anterior view of heart 
of a swine fed the severe atherogenic diet for 58 
weeks and X-irradiated twice. The anterior wall of 
the left ventricle has been partially cut away to dem- 
onstrate the large recent, well-demarcated infarct 
(arrow). A fibrinous deposit can be seen in patches 
on the pericardial surface. Segments of the coronary 
arteries have been previously removed. 
ternal elastic membrane. With the progression 
of the disease the lesions became thicker and cy- 
toplasm of many cells was filled with lipids 
(Figure 3). Hemorrhage was a prominent and 
frequent feature of these advanced lesions 
(Figure 4). Necrosis and calcification also var- 
ied from case to case. In some cases, they were 
quite prominent features (Figure 5) . 
Complete or virtual occlusion of main trunks 
or their branches by extensive lesions with or 
without recent hemorrhage into the plaque were 
frequently observed in almost all cases. Throm- 
botic occlusion was not a common feature and 
was seen in large arteries only in two cases. Oc- 
casionally thrombosis of small intramural 
branches was seen in areas of myocardial in- 
farcts. It is of interest to note that this diet- 
and x-ray-induced coronary artery disease af- 
fects arteries of all calibers (main trunks as 
well as small branches) . 
The histologic appearance of the myocardial 
infarcts was similar to that of human infarcts 
(Figures 6 and 7). 
The four swine that were fed the stock diet 
and x-irradiated twice and that survived nine 
LD 
LC 
IT 
w 
V 
TSC 3 
Figure 2. — Sequential, alternate segments of the three 
main coronary arteries of a swine fed the severe diet 
for 40 weeks and X-irradiated twice (TSC 3 in Table 
II). The angiograms from this swine, taken prior to 
sacrifice, are shown in Fig. 9 and can be directly 
compared to the areas of virtual occlusion seen 
grossly in these segments. The dark areas of the le- 
sions of the right coronary artery were grossly hem- 
orrhagic. 
